ID   IMA1B_ORYSJ             Reviewed;         534 AA.
AC   Q9SLX0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Importin subunit alpha-1b;
GN   OrderedLocusNames=Os05g0155601, LOC_Os05g06350;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION,
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH IMPORTIN BETA-1.
RC   STRAIN=cv. Nipponbare; TISSUE=Leaf;
RX   PubMed=11124253; DOI=10.1074/jbc.m006430200;
RA   Jiang C.-J., Shoji K., Matsuki R., Baba A., Inagaki N., Ban H., Iwasaki T.,
RA   Imamoto N., Yoneda Y., Deng X.-W., Yamamoto N.;
RT   "Molecular cloning of a novel importin alpha homologue from rice, by which
RT   constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-
RT   protein is preferentially nuclear imported.";
RL   J. Biol. Chem. 276:9322-9329(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Functions in nuclear protein import. Binds specifically and
CC       directly to substrates containing either a simple or bipartite NLS
CC       motif. Promotes docking of import substrates to the nuclear envelope.
CC       In conjunction with importin beta-1, mediates the nuclear envelope
CC       docking, and the subsequent translocation into the nucleus of the
CC       constitutive morphogenetic 1 (COP1) protein containing bipartite NLS
CC       motif. {ECO:0000269|PubMed:11124253}.
CC   -!- SUBUNIT: Forms a complex with importin subunit beta-1. The whole
CC       complex, most stable and composed of importin alpha and importin beta,
CC       is referred to as PTAC or pore targeting complex.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:11124253}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in root and weakly in callus,
CC       etiolated leaf and green leaf. {ECO:0000269|PubMed:11124253}.
CC   -!- INDUCTION: Slightly increased by dark treatment.
CC       {ECO:0000269|PubMed:11124253}.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; AB024311; BAA88950.1; -; mRNA.
DR   EMBL; AC087551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP014961; BAS92358.1; -; Genomic_DNA.
DR   RefSeq; XP_015639761.1; XM_015784275.1.
DR   AlphaFoldDB; Q9SLX0; -.
DR   SMR; Q9SLX0; -.
DR   STRING; 4530.OS05T0155601-00; -.
DR   PaxDb; Q9SLX0; -.
DR   PRIDE; Q9SLX0; -.
DR   EnsemblPlants; Os05t0155601-00; Os05t0155601-00; Os05g0155601.
DR   GeneID; 4337853; -.
DR   Gramene; Os05t0155601-00; Os05t0155601-00; Os05g0155601.
DR   KEGG; osa:4337853; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   HOGENOM; CLU_018084_5_0_1; -.
DR   InParanoid; Q9SLX0; -.
DR   OMA; NAYAQMI; -.
DR   OrthoDB; 1111872at2759; -.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   ExpressionAtlas; Q9SLX0; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..534
FT                   /note="Importin subunit alpha-1b"
FT                   /id="PRO_0000120741"
FT   DOMAIN          1..58
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          111..151
FT                   /note="ARM 1"
FT   REPEAT          154..193
FT                   /note="ARM 2"
FT   REPEAT          196..236
FT                   /note="ARM 3"
FT   REPEAT          238..277
FT                   /note="ARM 4"
FT   REPEAT          280..319
FT                   /note="ARM 5"
FT   REPEAT          322..362
FT                   /note="ARM 6"
FT   REPEAT          365..404
FT                   /note="ARM 7"
FT   REPEAT          408..447
FT                   /note="ARM 8"
FT   REGION          505..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        511..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        519
FT                   /note="F -> L (in Ref. 1; BAA88950)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   534 AA;  58567 MW;  7DA8A3F7ADEF1728 CRC64;
     MSLRPSERAE VRRSRYKVAV DADEGRRRRE DNMVEIRKSR REESLLKKRR DGLPAAAAAA
     AAASPLLAHS SALQQKLEGL PAMVQAVQSD DSAVQLEATT QFRKLLSIER SPPIEEVINT
     GVVPRFIAFL QREDYPQLQF EAAWALTNIA SGTSDNTKVV VESGAVPIFV KLLSSPSEDV
     REQAVWALGN VAGDSPKCRD LVLASGGLYP LLQQLNEHAK LSMLRNATWT LSNFCRGKPQ
     PNFEQVKPAL SALQRLIHSQ DEEVLTDACW ALSYLSDGTN DKIQAVIESG VFPRLVELLM
     HPSASVLIPA LRTVGNIVTG DDMQTQCVID HQALPCLLNL LTNNHKKSIK KEACWTISNI
     TAGNREQIQA VINANIIAPL VHLLQTAEFD IKKEAAWAIS NATSGGTHDQ IKYLVAQGCI
     KPLCDLLVCP DPRIVTVCLE GLENILKVGE AEKNLGAGDV NSYAQMIDDA EGLEKIENLQ
     SHDNTEIYEK AVKMLESYWL EEEDDAMPSG DNAQNGFNFG NQQPNVPSGG FNFG