ID   IMA1_CAEEL              Reviewed;         524 AA.
AC   Q22560; O44926;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Importin subunit alpha-1;
DE   AltName: Full=Karyopherin subunit alpha-1;
GN   Name=ima-1; ORFNames=T19B10.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|EMBL:CAA98540.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=11311162; DOI=10.1242/dev.128.10.1817;
RA   Geles K.G., Adam S.A.;
RT   "Germline and developmental roles of the nuclear transport factor importin
RT   alpha3 in C. elegans.";
RL   Development 128:1817-1830(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Binds specifically and directly to substrates containing
CC       either a simple or bipartite NLS motif. Promotes docking of import
CC       substrates to the nuclear envelope. Seems to act as a cytosolic
CC       receptor for both simple and bipartite NLS motifs (By similarity).
CC       {ECO:0000250|UniProtKB:Q19969}.
CC   -!- SUBUNIT: Forms a complex with an importin beta subunit.
CC       {ECO:0000269|PubMed:11311162}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11311162}.
CC   -!- TISSUE SPECIFICITY: Adult germline tissues.
CC       {ECO:0000269|PubMed:11311162}.
CC   -!- DEVELOPMENTAL STAGE: Expressed very weakly in early larvae, levels of
CC       expression increase in L4 and adult stages when germ cells are
CC       continually proliferating. {ECO:0000269|PubMed:11311162}.
CC   -!- DOMAIN: Does not contain ARM repeats, but instead Ser charged repeats.
CC       May have specificity for cargos distinct from that of other importin
CC       alpha subunits.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; AF040997; AAB97173.1; -; mRNA.
DR   EMBL; Z74043; CAA98540.1; -; Genomic_DNA.
DR   PIR; T24976; T24976.
DR   PIR; T42404; T42404.
DR   RefSeq; NP_505854.1; NM_073453.6.
DR   AlphaFoldDB; Q22560; -.
DR   SMR; Q22560; -.
DR   BioGRID; 44582; 2.
DR   IntAct; Q22560; 1.
DR   STRING; 6239.T19B10.7.2; -.
DR   iPTMnet; Q22560; -.
DR   EPD; Q22560; -.
DR   PaxDb; Q22560; -.
DR   PeptideAtlas; Q22560; -.
DR   EnsemblMetazoa; T19B10.7.1; T19B10.7.1; WBGene00002072.
DR   EnsemblMetazoa; T19B10.7.2; T19B10.7.2; WBGene00002072.
DR   GeneID; 179555; -.
DR   UCSC; T19B10.7.2; c. elegans.
DR   CTD; 179555; -.
DR   WormBase; T19B10.7; CE06461; WBGene00002072; ima-1.
DR   eggNOG; KOG0166; Eukaryota.
DR   GeneTree; ENSGT01050000244891; -.
DR   HOGENOM; CLU_611424_0_0_1; -.
DR   InParanoid; Q22560; -.
DR   OMA; SNICVEG; -.
DR   OrthoDB; 840327at2759; -.
DR   PhylomeDB; Q22560; -.
DR   SignaLink; Q22560; -.
DR   PRO; PR:Q22560; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00002072; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005643; C:nuclear pore; IMP:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IMP:UniProtKB.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IMP:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51214; IBB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..524
FT                   /note="Importin subunit alpha-1"
FT                   /id="PRO_0000120734"
FT   DOMAIN          1..59
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        83
FT                   /note="H -> Q (in Ref. 1; AAB97173)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   524 AA;  59925 MW;  C2DBBE2437859FA7 CRC64;
     MGDEFRPSHE ERSKMYKSNV RDQNEMRRKR REDEVQIRKN RRDEKFERNR QITVQRSLSH
     EETSELLKSV ADGLQSMQET TIHEALTVLH ENLNNTVWTI HVLVKVQILH KLSDVYCNRV
     ISQTTRLLIS RTLLKISGID EVKYERYSSD DRCIQSLVFN ISTYGSSEDI LCDTFQSIAC
     FIIRSITYRN LALDCAIVSE LIDASTINMS IILHRSLMWL VFLFCEKLDR CSPHVDEIAP
     LLEIISNGIQ STDAMVQTDA ASSCASLAEW PPIYHYMSDL KLCSKLVANL RNDKGNARPK
     VKAGINSIIQ ATGYFTEEMI DAGLLEVLKG FVNVSYMSQE VCFIISNICV EGEQTIDKLI
     SSGVLREVAR VMEASEYRSR REAAFVICHC CASANQKHLE YVVELGMLSA FTDLLTCMDV
     SLVSYILDAI YLLLQFGEMR LLPDNSNPVA IKLEEIGCRE KLEFLCESQS VDIHARAYTI
     IDRFYVDDDA PLNDDPFAGY QRNNIDDTIE KMIREPIMDQ PFSF