ID   IMA1_XENLA              Reviewed;         523 AA.
AC   P52171;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Importin subunit alpha-1;
DE   AltName: Full=Karyopherin subunit alpha-2;
GN   Name=kpna2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-55; 296-332; 342-346
RP   AND 507-523.
RC   TISSUE=Ovary;
RX   PubMed=8001116; DOI=10.1016/0092-8674(94)90067-1;
RA   Goerlich D., Prehn S., Laskey R.A., Hartmann E.;
RT   "Isolation of a protein that is essential for the first step of nuclear
RT   protein import.";
RL   Cell 79:767-778(1994).
CC   -!- FUNCTION: It is essential for selective protein import into nucleus.
CC       Promotes signal-dependent binding of karyophilic proteins to the
CC       nuclear envelope.
CC   -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; L36340; AAC14196.1; -; mRNA.
DR   PIR; B55194; B55194.
DR   AlphaFoldDB; P52171; -.
DR   SMR; P52171; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Protein transport;
KW   Reference proteome; Repeat; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8001116"
FT   CHAIN           2..523
FT                   /note="Importin subunit alpha-1"
FT                   /id="PRO_0000120732"
FT   DOMAIN          2..57
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          109..151
FT                   /note="ARM 1"
FT   REPEAT          152..196
FT                   /note="ARM 2"
FT   REPEAT          197..235
FT                   /note="ARM 3"
FT   REPEAT          236..280
FT                   /note="ARM 4"
FT   REPEAT          281..320
FT                   /note="ARM 5"
FT   REPEAT          321..362
FT                   /note="ARM 6"
FT   REPEAT          363..402
FT                   /note="ARM 7"
FT   REPEAT          403..447
FT                   /note="ARM 8"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        309
FT                   /note="T -> P (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   523 AA;  57885 MW;  97EFE68C97690410 CRC64;
     MPTTNEADER MRKFKNKGKD TAELRRRRVE VSVELRKAKK DEQILKRRNV CFPEELILSP
     EKNAMQSIQV PQLSLEEIVQ GMNSGDNENE LRSTQAARKM LSKERNPPLN DIIEAGLIPK
     LVEFLSYHNN STLQFEAAWA LTNIASGTSD QTKSVVDGGA IPAFISLISS PHLHISEQAV
     WALGNIAGDG PLYRDALISC NVIPPLLTLV NPQTPLGYLR NITWTLSNLC RNKNPYPPMS
     AVLQILPVLT QLMLHEDKDI LSDTCWAMSY LTDGSNDRID VVVKTGLVER LIQLMYSPEL
     SILTPSLRTV GNIVTGTDKQ TQAAIDAGVL SVLPQLLRHQ KPSIQKEAAW ALSNIAAGPA
     PQIQQMITCG LLSPLVDLLK KGDFKAQKEA VWAVTNYTSG GTVEQVVQLV QCGVLEPLLN
     LLTIKDSKTI LVILDAISNI FLAAEKLGEQ EKLCLLVEEL GGLEKIEALQ THDNRMVYHA
     ALALIEKYFS GEEADEMNAL EPEVGNDAYT FQVPNMQKES FKF