ID   IMA6_DANRE              Reviewed;         539 AA.
AC   Q503E9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Importin subunit alpha-6 {ECO:0000250|UniProtKB:O15131};
DE   AltName: Full=Karyopherin subunit alpha-5;
GN   Name=kpna5 {ECO:0000250|UniProtKB:O15131}; ORFNames=zgc:110662;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Singapore local strain; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in nuclear protein import. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; BC095356; AAH95356.1; -; mRNA.
DR   RefSeq; NP_001018163.1; NM_001018153.1.
DR   AlphaFoldDB; Q503E9; -.
DR   STRING; 7955.ENSDARP00000092803; -.
DR   PaxDb; Q503E9; -.
DR   Ensembl; ENSDART00000102027; ENSDARP00000092803; ENSDARG00000042030.
DR   GeneID; 553205; -.
DR   KEGG; dre:553205; -.
DR   CTD; 3841; -.
DR   ZFIN; ZDB-GENE-050522-22; kpna5.
DR   eggNOG; KOG0166; Eukaryota.
DR   GeneTree; ENSGT01050000244950; -.
DR   InParanoid; Q503E9; -.
DR   OrthoDB; 1111872at2759; -.
DR   PhylomeDB; Q503E9; -.
DR   TreeFam; TF354205; -.
DR   PRO; PR:Q503E9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..539
FT                   /note="Importin subunit alpha-6"
FT                   /id="PRO_0000376935"
FT   DOMAIN          1..60
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          117..157
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          160..199
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          202..242
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          245..284
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          287..326
FT                   /note="ARM 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          329..368
FT                   /note="ARM 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          371..410
FT                   /note="ARM 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          414..453
FT                   /note="ARM 8"
FT                   /evidence="ECO:0000255"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  60109 MW;  8D58B9019169847F CRC64;
     MDAMASPGKD NYRMKSYKNK ALNPQEMRRR REEEGIQLRK QKREEQLFKR RNVSLPPGDE
     SMLECPIQDP DVSSTVPVSG EGVITQDVIQ MIFSEDPDQQ LIATQKFRKL LSKEPNPPID
     EVIGTPGVVN RFVEFLRRSD NCTLQFEAAW ALTNIASGTF QHTKVVIETG AVPIFIELLN
     SEYEDVQEQA VWALGNIAGD NAECRDYVLN CGILPSLQQL LAKSNRLTTT RNAVWALSNL
     CRGKNPPPDF AKVSPCLSVL SRLLFSSDPD VLADACWALS YLSDGPNDKI QTVIDSGVCR
     RLVELLMHSD YKVVSPALRA VGNIVTGDDI QTQVILNCSA LPCLLHLLSS PKESIKKEAC
     WTVSNITAGN RAQIQAVIDS NVFPVLIEIL QKAEFRTRKE AAWAITNATS GGTPEQIRYL
     VSLNTIKPMC DLLTVMDSKI VQVALNGLEN ILRLGEQESK QNGTGINPYC ALIEEAYGLD
     KIEFLQSHEN QEIYQKAFDL IEHYFGVEEE DASIVPQVDQ NQGQYIFQQS EGPMEGFQL