ID   IMA7_PONAB              Reviewed;         536 AA.
AC   Q5RBV0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Importin subunit alpha-7;
DE   AltName: Full=Karyopherin subunit alpha-6;
GN   Name=KPNA6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in nuclear protein import as an adapter protein for
CC       nuclear receptor KPNB1. Binds specifically and directly to substrates
CC       containing either a simple or bipartite NLS motif. Docking of the
CC       importin/substrate complex to the nuclear pore complex (NPC) is
CC       mediated by KPNB1 through binding to nucleoporin FxFG repeats and the
CC       complex is subsequently translocated through the pore by an energy
CC       requiring, Ran-dependent mechanism. At the nucleoplasmic side of the
CC       NPC, Ran binds to importin-beta and the three components separate and
CC       importin-alpha and -beta are re-exported from the nucleus to the
CC       cytoplasm where GTP hydrolysis releases Ran from importin. The
CC       directionality of nuclear import is thought to be conferred by an
CC       asymmetric distribution of the GTP- and GDP-bound forms of Ran between
CC       the cytoplasm and nucleus (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with importin subunit beta-1. Interacts with
CC       ZIC3 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; CR858533; CAH90760.1; -; mRNA.
DR   RefSeq; NP_001125426.1; NM_001131954.1.
DR   AlphaFoldDB; Q5RBV0; -.
DR   SMR; Q5RBV0; -.
DR   Ensembl; ENSPPYT00000001907; ENSPPYP00000001848; ENSPPYG00000001603.
DR   GeneID; 100172333; -.
DR   KEGG; pon:100172333; -.
DR   CTD; 23633; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   GeneTree; ENSGT01050000244950; -.
DR   InParanoid; Q5RBV0; -.
DR   OrthoDB; 1111872at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Protein transport; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN           1..536
FT                   /note="Importin subunit alpha-7"
FT                   /id="PRO_0000326084"
FT   DOMAIN          1..60
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          76..115
FT                   /note="ARM 1; truncated"
FT   REPEAT          116..159
FT                   /note="ARM 2"
FT   REPEAT          160..204
FT                   /note="ARM 3"
FT   REPEAT          205..243
FT                   /note="ARM 4"
FT   REPEAT          244..288
FT                   /note="ARM 5"
FT   REPEAT          289..328
FT                   /note="ARM 6"
FT   REPEAT          329..370
FT                   /note="ARM 7"
FT   REPEAT          371..410
FT                   /note="ARM 8"
FT   REPEAT          411..453
FT                   /note="ARM 9"
FT   REPEAT          457..502
FT                   /note="ARM 10; atypical"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..239
FT                   /note="NLS binding site (major)"
FT                   /evidence="ECO:0000250"
FT   REGION          316..404
FT                   /note="NLS binding site (minor)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           45..54
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:O60684"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60684"
FT   MOD_RES         113
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O60684"
SQ   SEQUENCE   536 AA;  60030 MW;  9D0E27482B9BDED3 CRC64;
     METMASPGKD NYRMKSYKNN ALNPEEMRRR REEEGIQLRK QKREQQLFKR RNVELINEEA
     AMFDSLLMDS YVSSTTGESV ITREMVEMLF SDDSDLQLAT TQKFRKLLSK EPSPPIDEVI
     NTPRVVDRFV EFLKRNENCT LQFEAAWALT NIASGTSQQT KIVIEAGAVP IFIELLNSDF
     EDVQEQAVWA LGNIAGDSSV CRDYVLNCSI LNPLLTLLTK STRLTMTRNA VWALSNLCRG
     KNPPPEFAKV SPCLPVLSRL LFSSDSDLLA DACWALSYLS DGPNEKIQAV IDSGVCRRLV
     ELLMHNDYKV ASPALRAVGN IVTGDDIQTQ VILNCSALPC LLHLLSSPKE SIRKEACWTI
     SNITAGNRAQ IQAVIDANIF PVLIEILQKA EFRTRKEAAW AITNATSGGT PEQIRYLVSL
     GCIKPLCDLL TVMDSKIVQV ALNGLENILR LGEQEGKRSG SGVNPYCGLI EEAYGLDKIE
     FLQSHENQEI YQKAFDLIEH YFGVEDDDSS LAPQVDETQQ QFIFQQPEAP MEGFQL