ID   IMA8_PIG                Reviewed;         507 AA.
AC   C6K7I2; F1RFK2;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Importin subunit alpha-8;
DE   AltName: Full=Karyopherin subunit alpha-7;
GN   Name=KPNA7;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang X., Cabot R.;
RT   "Expression profiles of karyopherin alpha molecules in porcine oocytes and
RT   embryos produced by in vitro fertilization.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Swine Genome Sequencing Consortium;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in nuclear protein import. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to importin subunit beta-1/KPNB1 via the IBB domain;
CC       this complex dissociates in the presence of RAN-GTP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; GQ166958; ACS34962.1; -; mRNA.
DR   EMBL; FP102574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001156883.1; NM_001163411.1.
DR   AlphaFoldDB; C6K7I2; -.
DR   SMR; C6K7I2; -.
DR   STRING; 9823.ENSSSCP00000008128; -.
DR   PaxDb; C6K7I2; -.
DR   GeneID; 100302505; -.
DR   KEGG; ssc:100302505; -.
DR   CTD; 402569; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   InParanoid; C6K7I2; -.
DR   OrthoDB; 1111872at2759; -.
DR   ChiTaRS; KPNA7; pig.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 7.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 4.
DR   PROSITE; PS51214; IBB; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..507
FT                   /note="Importin subunit alpha-8"
FT                   /id="PRO_0000413538"
FT   DOMAIN          1..57
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          99..139
FT                   /note="ARM 1"
FT   REPEAT          142..181
FT                   /note="ARM 2"
FT   REPEAT          184..224
FT                   /note="ARM 3"
FT   REPEAT          227..266
FT                   /note="ARM 4"
FT   REPEAT          269..308
FT                   /note="ARM 5"
FT   REPEAT          311..350
FT                   /note="ARM 6"
FT   REPEAT          353..392
FT                   /note="ARM 7"
FT   REPEAT          396..435
FT                   /note="ARM 8"
FT   CONFLICT        146
FT                   /note="R -> H (in Ref. 1; ACS34962)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        301
FT                   /note="R -> C (in Ref. 1; ACS34962)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        383
FT                   /note="A -> T (in Ref. 1; ACS34962)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   507 AA;  55522 MW;  7BC4DC33E5202409 CRC64;
     MPILEAPEER LRKFKYRGKD ASVRRQQRLA VSLELRKAKK DEQALKRRNI TTASDPFVQQ
     TNGAKLTLQE IIHGVNASDP EQCFQATQAA RKMLSQERNP PLKLMVEAGL IPRLVQLLRS
     SLHPCLQFEA AWALTNIASG ASELTRAVVE GGAIQPLVEL LASSHMSVCE QAVWALGNIA
     GDGAEFRDIV ISSNAIPHLL ALASSNVPVT FLRNIVWTLS NLCRNKNPCP CDNAVKQMLP
     VLSHLLQHRD SEVLSDTCWA LSYLTDGCDE RIGQVVDMGV LPRLVELMTS SELNVLTPSL
     RTVGNIVTGT DPQTQLAIDA GLLSVLPHLL LHPRSSIQKE AAWALSNVAA GPHQHIQQLI
     ACGALPPLVA LLKNGEFKVQ KEAVWTVANF TTGGTVDQLV QLVQAGVLEP LINLLDIQDT
     KMVIIILDVI FFILQAAEKI SQKENMCLLI EGLGGIDKIE ALQLHENRQV ALTALSIIER
     YFSEEEDAGT LSALLQDHEC LTPLTKT