IMAB_DICDI
ID IMAB_DICDI Reviewed; 516 AA.
AC Q76P29; Q55A47;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Importin subunit alpha-B;
DE AltName: Full=Karyopherin subunit alpha-B;
GN ORFNames=DDB_G0272318;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Functions in nuclear protein import via a substrate-importin
CC alpha-beta transport complex that passes though the nuclear pore
CC complexes (NPC). Binds specifically and directly to substrates
CC containing either a simple or bipartite NLS motif (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex with tnpo/importin subunit beta.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus envelope
CC {ECO:0000250}.
CC -!- DOMAIN: The N-terminal hydrophilic region contains the importin beta
CC binding domain (IBB domain), which is sufficient for binding importin
CC beta and essential for nuclear protein import. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71311.1; -; Genomic_DNA.
DR RefSeq; XP_645137.1; XM_640045.1.
DR AlphaFoldDB; Q76P29; -.
DR SMR; Q76P29; -.
DR STRING; 44689.DDB0302555; -.
DR PaxDb; Q76P29; -.
DR EnsemblProtists; EAL71311; EAL71311; DDB_G0272318.
DR GeneID; 8618307; -.
DR KEGG; ddi:DDB_G0272318; -.
DR dictyBase; DDB_G0272318; -.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; Q76P29; -.
DR OMA; SEAPMEG; -.
DR PhylomeDB; Q76P29; -.
DR PRO; PR:Q76P29; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.20.5.690; -; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 4.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..516
FT /note="Importin subunit alpha-B"
FT /id="PRO_0000327491"
FT DOMAIN 1..55
FT /note="IBB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT REPEAT 55..96
FT /note="ARM 1"
FT REPEAT 100..140
FT /note="ARM 2"
FT REPEAT 143..182
FT /note="ARM 3"
FT REPEAT 185..227
FT /note="ARM 4"
FT REPEAT 229..268
FT /note="ARM 5"
FT REPEAT 271..310
FT /note="ARM 6"
FT REPEAT 313..352
FT /note="ARM 7"
FT REPEAT 355..394
FT /note="ARM 8"
FT REPEAT 398..437
FT /note="ARM 9"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 57557 MW; 89A0D54D029ECD9E CRC64;
MQRSKQETRK SQYKKSIDSD ESRRKREEAS LSIRKNKREE SLLKKRTQAV PGSTPVKVDS
LINQRLEQLP SLVAEINSEN PDLILKSTTA FRKLLSIEKS PPIEEVIKTG IVPRLVKFLY
MQDFPQLQFE AAWALTNIAS GTPEQTRVVI ENGAIQVFVL LLSSPHDDVR EQAVWALGNI
AGDSHYCRDL VLSHNALPPL LSLLQNPAAI KVSMVRNATW TLSNFCRGKP QPPFEIVRAS
LPVLAKLIYY QDEEVLIDAC WALSYLSDGS NERIQEVIDA KVCRKMVELL GHPTIAVQTP
ALRTIGNIVT GDDNQTQIVL SVQALSHLLN LLQSPKRAIR KEACWTISNI TAGDKNQIQQ
VIDANIIPSL VYLLANAEFE IQKEAAWAIS NATSCGTPQQ IHFLVSQGCV KPLCDLLKVS
DPRIINVALE GIENILVAGK KEAQVTGVNP YKKIIEDADG LGKIYDLQHH MNKDTFEKVS
RIISTYLEDE QEDEGDLMPE GSSFSFSNQT NSNFNL
