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APOC1_FELCA
ID   APOC1_FELCA             Reviewed;          78 AA.
AC   P0DM82;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2013, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Apolipoprotein C-I;
DE            Short=Apo-CI;
DE            Short=ApoC-I;
DE   AltName: Full=Apolipoprotein C1;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein C-I;
DE   Flags: Precursor;
GN   Name=APOC1;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (OCT-2013).
CC   -!- FUNCTION: Inhibitor of lipoprotein binding to the low density
CC       lipoprotein (LDL) receptor, LDL receptor-related protein, and very low
CC       density lipoprotein (VLDL) receptor. Associates with high density
CC       lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the
CC       plasma and makes up about 10% of the protein of the VLDL and 2% of that
CC       of HDL. Appears to interfere directly with fatty acid uptake and is
CC       also the major plasma inhibitor of cholesteryl ester transfer protein
CC       (CETP). Binds free fatty acids and reduces their intracellular
CC       esterification. Modulates the interaction of APOE with beta-migrating
CC       VLDL and inhibits binding of beta-VLDL to the LDL receptor-related
CC       protein. {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR   RefSeq; XP_019674940.1; XM_019819381.1.
DR   AlphaFoldDB; P0DM82; -.
DR   SMR; P0DM82; -.
DR   Ensembl; ENSFCAT00000033571; ENSFCAP00000030468; ENSFCAG00000033939.
DR   GeneID; 101086520; -.
DR   KEGG; fca:101086520; -.
DR   CTD; 341; -.
DR   GeneTree; ENSGT01050000247924; -.
DR   OrthoDB; 1632509at2759; -.
DR   Proteomes; UP000011712; Chromosome E2.
DR   Bgee; ENSFCAG00000033939; Expressed in liver and 10 other tissues.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR   GO; GO:0004859; F:phospholipase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   GO; GO:0032375; P:negative regulation of cholesterol transport; IBA:GO_Central.
DR   GO; GO:0050995; P:negative regulation of lipid catabolic process; IBA:GO_Central.
DR   GO; GO:0051005; P:negative regulation of lipoprotein lipase activity; IBA:GO_Central.
DR   GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR   GO; GO:0034447; P:very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..78
FT                   /note="Apolipoprotein C-I"
FT                   /id="PRO_0000424548"
FT   CHAIN           29..78
FT                   /note="Truncated apolipoprotein C-I"
FT                   /evidence="ECO:0000250|UniProtKB:P86336"
FT                   /id="PRO_0000424549"
SQ   SEQUENCE   78 AA;  8488 MW;  25BFA7123BC771A7 CRC64;
     MRLILWLPVL VVVLLMVLEG PAPAQGAPAI ASTFSNIPNS LKEFGNNLKD AFESIPEATR
     KLMTSFAEGL KNLRLPLL
 
 
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