ID   IMAP_DROFU              Reviewed;          63 AA.
AC   P11424;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Male accessory gland serine protease inhibitor;
DE   AltName: Full=Acrosin inhibitor;
DE   AltName: Full=Paragonial peptide D;
GN   Name=PapD;
OS   Drosophila funebris (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7221;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2722874; DOI=10.1016/s0021-9258(18)81720-3;
RA   Schmidt T., Stumm-Zollinger E., Chen P.-S., Boehlen P., Stone S.R.;
RT   "A male accessory gland peptide with protease inhibitory activity in
RT   Drosophila funebris.";
RL   J. Biol. Chem. 264:9745-9749(1989).
CC   -!- FUNCTION: Serine protease inhibitor. This peptide can inhibit, in-vivo,
CC       acrosin and, to a lower level, plasma kallikrein. It probably plays a
CC       role in Drosophila reproduction.
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DR   PIR; A33502; TIFFAF.
DR   AlphaFoldDB; P11424; -.
DR   SMR; P11424; -.
DR   MEROPS; I02.019; -.
DR   FlyBase; FBgn0004113; Dfun\PapD.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW   Serine protease inhibitor.
FT   CHAIN           1..63
FT                   /note="Male accessory gland serine protease inhibitor"
FT                   /id="PRO_0000155449"
FT   DOMAIN          6..62
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            22..23
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   DISULFID        6..62
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        21..45
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        37..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   63 AA;  6911 MW;  8597A7974B49329E CRC64;
     FKNPECGEPH SLDGSPNGIS CRGYFPSWSY NPDAQQCVSF VYGGCGGNNN RFGSQNECEE
     RCI