ID   IMA_SOLLC               Reviewed;         527 AA.
AC   O22478;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Importin subunit alpha;
DE   AltName: Full=Karyopherin subunit alpha;
DE            Short=KAP alpha;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kunik T., Mizrachy L., Citovsky V., Gafni Y.;
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically and directly to substrates containing
CC       either a simple or bipartite NLS motif. Promotes docking of import
CC       substrates to the nuclear envelope. Seems to act as a cytosolic
CC       receptor for both simple and bipartite NLS motifs (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with importin subunit beta-1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; AF017252; AAC23722.1; -; mRNA.
DR   PIR; T04329; T04329.
DR   RefSeq; NP_001234006.1; NM_001247077.1.
DR   AlphaFoldDB; O22478; -.
DR   SMR; O22478; -.
DR   STRING; 4081.Solyc06g009750.2.1; -.
DR   PaxDb; O22478; -.
DR   PRIDE; O22478; -.
DR   GeneID; 543535; -.
DR   KEGG; sly:543535; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   HOGENOM; CLU_018084_5_0_1; -.
DR   InParanoid; O22478; -.
DR   OrthoDB; 1111872at2759; -.
DR   PhylomeDB; O22478; -.
DR   Proteomes; UP000004994; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 5.
DR   PROSITE; PS51214; IBB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Protein transport; Reference proteome; Repeat; Transport.
FT   CHAIN           1..527
FT                   /note="Importin subunit alpha"
FT                   /id="PRO_0000120739"
FT   DOMAIN          1..58
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          109..151
FT                   /note="ARM 1"
FT   REPEAT          152..196
FT                   /note="ARM 2"
FT   REPEAT          197..234
FT                   /note="ARM 3"
FT   REPEAT          235..279
FT                   /note="ARM 4"
FT   REPEAT          280..319
FT                   /note="ARM 5"
FT   REPEAT          320..362
FT                   /note="ARM 6"
FT   REPEAT          363..403
FT                   /note="ARM 7"
FT   REPEAT          404..445
FT                   /note="ARM 8"
SQ   SEQUENCE   527 AA;  58606 MW;  4A3F01691CEF4817 CRC64;
     MSLRPNSRTE ARRSRYKVAV DAEEGRRRRE DNMVEIRKNK REENLLKKRR EGLLQAQQFP
     STAAVSHLDK KLETLPELIA GVWSDDSSLQ LECTTQFRKL LSIERNPPIE EVIQSGVVPR
     FVEFLARDDY PQLQFEAAWA LTNIASGTSE NTKVVIDYGS VPIFIRLLSS PSDDVREQAV
     WALGNIAGDS PKYRDLVLGH GALVALLAQF NEQAKLSMLR NATWTLSNFC RGKPQPLFEQ
     TKAALPTLGR LIHSNDEEVL TDACWALSYL SDGTNDKIQA VIEAGVCSRL VELLLHSSPS
     VLIPALRTVG NIVTGDDIQT QVMIDHHALP CLVNLLTQNY KKSIKKEACW TISNITAGNR
     NQIQIVIEAG IIAPLVYLLQ NAEFEIKKEA AWAISNATSG GNHDQIKFLV SQGCIKPLCD
     LLVCPDPRIV TVCLEGLENI LKIGEADKDL GNTEGVNVYA QLIDEAEGLE KIENLQSHDN
     TEIYEKAVKI LETYWLEEED VPVSLNEDQF EFGGADISLP SGGFNFS