IME1_YEAST
ID IME1_YEAST Reviewed; 360 AA.
AC P21190; D6VWR2;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Meiosis-inducing protein 1;
GN Name=IME1; OrderedLocusNames=YJR094C; ORFNames=J1916;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SK1;
RX PubMed=2247050; DOI=10.1128/mcb.10.12.6103-6113.1990;
RA Smith H.E., Su S.S.Y., Neigeborn L., Driscoll S.E., Mitchell A.P.;
RT "Role of IME1 expression in regulation of meiosis in Saccharomyces
RT cerevisiae.";
RL Mol. Cell. Biol. 10:6103-6113(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8483452; DOI=10.1007/bf00279441;
RA Sherman A., Shefer M., Sagee S., Kassir Y.;
RT "Post-transcriptional regulation of IME1 determines initiation of meiosis
RT in Saccharomyces cerevisiae.";
RL Mol. Gen. Genet. 237:375-384(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP FUNCTION.
RX PubMed=24269006; DOI=10.1016/j.cell.2013.10.047;
RA Schwartz S., Agarwala S.D., Mumbach M.R., Jovanovic M., Mertins P.,
RA Shishkin A., Tabach Y., Mikkelsen T.S., Satija R., Ruvkun G., Carr S.A.,
RA Lander E.S., Fink G.R., Regev A.;
RT "High-resolution mapping reveals a conserved, widespread, dynamic mRNA
RT methylation program in yeast meiosis.";
RL Cell 155:1409-1421(2013).
CC -!- FUNCTION: Transcription factor required for sporulation and for early
CC sporulation-specific genes expression. Positive regulator of SME1/IME2
CC expression. Directly activates expression of SLZ1 during meiosis.
CC {ECO:0000269|PubMed:24269006}.
CC -!- SUBUNIT: Interacts with UME6.
CC -!- INTERACTION:
CC P21190; P38615: RIM11; NbExp=4; IntAct=EBI-9199, EBI-10642;
CC P21190; P39001: UME6; NbExp=3; IntAct=EBI-9199, EBI-20086;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- INDUCTION: Starvation of yeast cells may stimulate activity of IME1
CC through a post-translational mechanism.
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DR EMBL; M37188; AAA86790.1; -; Genomic_DNA.
DR EMBL; X52152; CAA36400.1; -; Genomic_DNA.
DR EMBL; Z49594; CAA89622.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08878.1; -; Genomic_DNA.
DR PIR; S57115; S57115.
DR RefSeq; NP_012627.1; NM_001181751.1.
DR AlphaFoldDB; P21190; -.
DR BioGRID; 33848; 252.
DR ComplexPortal; CPX-1415; IME1-UME6 transcription activation complex.
DR DIP; DIP-1567N; -.
DR IntAct; P21190; 2.
DR MINT; P21190; -.
DR STRING; 4932.YJR094C; -.
DR iPTMnet; P21190; -.
DR PaxDb; P21190; -.
DR PRIDE; P21190; -.
DR EnsemblFungi; YJR094C_mRNA; YJR094C; YJR094C.
DR GeneID; 853556; -.
DR KEGG; sce:YJR094C; -.
DR SGD; S000003854; IME1.
DR VEuPathDB; FungiDB:YJR094C; -.
DR eggNOG; ENOG502SCKA; Eukaryota.
DR HOGENOM; CLU_889059_0_0_1; -.
DR InParanoid; P21190; -.
DR OMA; YETNTNA; -.
DR BioCyc; YEAST:G3O-31721-MON; -.
DR PRO; PR:P21190; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P21190; protein.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0005667; C:transcription regulator complex; IC:ComplexPortal.
DR GO; GO:0008134; F:transcription factor binding; IPI:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR GO; GO:0010673; P:positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IC:ComplexPortal.
DR GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
DR GO; GO:0040020; P:regulation of meiotic nuclear division; IMP:UniProtKB.
DR GO; GO:0042173; P:regulation of sporulation resulting in formation of a cellular spore; IDA:ComplexPortal.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Activator; Meiosis; Nucleus; Reference proteome; Repressor; Sporulation;
KW Transcription; Transcription regulation.
FT CHAIN 1..360
FT /note="Meiosis-inducing protein 1"
FT /id="PRO_0000084181"
FT REGION 102..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 41858 MW; 98E21C22926F5A80 CRC64;
MQADMHGKLH AALEDGFFLF PFEQQQQPNI YYDTTTDQED RPCFSFGSTI SPRSWHFEKS
DKIASSQLQN LVHTQPIHLI NPQILFNEEF LNLENIDSQP ISKETKTTKD CTMATGPERG
KKSSESTRSS SLSSLFSNDE SASTFHSSFN NHDNFQKSNR NGDDIDISDT IKYETNTNAQ
KDIKIFQENF EFNEFPYTQD FYPYTTNYTY SKPTNIHESI NSKNTDSYSQ YQDQFPPHTD
NIHSFNNRHY SNHKSTNCNY YNNTSNNNNA SDNVYEADPF IDEPQVPSYY YPLEIAFDVE
KSPPPSLQKL NSKELEFLKK LNSKLSRYAA AYSFSSSNDQ DYYDKVRFQE ISYKFSKTYS
