ID   APOC1_ODORO             Reviewed;          88 AA.
AC   P0DPH4;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Apolipoprotein C-I;
DE            Short=Apo-CI;
DE            Short=ApoC-I;
DE   AltName: Full=Apolipoprotein C1;
DE   Contains:
DE     RecName: Full=Truncated apolipoprotein C-I;
DE   Flags: Precursor;
GN   Name=APOC1;
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus.
OX   NCBI_TaxID=9708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25621460; DOI=10.1038/ng.3198;
RA   Foote A.D., Liu Y., Thomas G.W., Vinar T., Alfoeldi J., Deng J., Dugan S.,
RA   van Elk C.E., Hunter M.E., Joshi V., Khan Z., Kovar C., Lee S.L.,
RA   Lindblad-Toh K., Mancia A., Nielsen R., Qin X., Qu J., Raney B.J.,
RA   Vijay N., Wolf J.B., Hahn M.W., Muzny D.M., Worley K.C., Gilbert M.T.,
RA   Gibbs R.A.;
RT   "Convergent evolution of the genomes of marine mammals.";
RL   Nat. Genet. 47:272-275(2015).
RN   [2]
RP   IDENTIFICATION.
RA   Puppione D.L.;
RL   Unpublished observations (MAY-2018).
CC   -!- FUNCTION: Inhibitor of lipoprotein binding to the low density
CC       lipoprotein (LDL) receptor, LDL receptor-related protein, and very low
CC       density lipoprotein (VLDL) receptor. Associates with high density
CC       lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the
CC       plasma and makes up about 10% of the protein of the VLDL and 2% of that
CC       of HDL. Appears to interfere directly with fatty acid uptake and is
CC       also the major plasma inhibitor of cholesteryl ester transfer protein
CC       (CETP). Binds free fatty acids and reduces their intracellular
CC       esterification. Modulates the interaction of APOE with beta-migrating
CC       VLDL and inhibits binding of beta-VLDL to the LDL receptor-related
CC       protein. {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR   EMBL; ANOP01000000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004401059.1; XM_004401002.1.
DR   AlphaFoldDB; P0DPH4; -.
DR   SMR; P0DPH4; -.
DR   STRING; 9708.P0DPH4; -.
DR   GeneID; 101385899; -.
DR   CTD; 341; -.
DR   Proteomes; UP000245340; Unplaced.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.260.30; -; 1.
DR   InterPro; IPR043081; ApoC-1_sf.
DR   InterPro; IPR006781; ApoC-I.
DR   PANTHER; PTHR16565; PTHR16565; 1.
DR   Pfam; PF04691; ApoC-I; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..88
FT                   /note="Apolipoprotein C-I"
FT                   /id="PRO_0000444592"
FT   CHAIN           29..88
FT                   /note="Truncated apolipoprotein C-I"
FT                   /evidence="ECO:0000250|UniProtKB:P86336"
FT                   /id="PRO_0000444593"
SQ   SEQUENCE   88 AA;  9816 MW;  4609659F1F242119 CRC64;
     MRLFLSLPVL VVVLAMVLEG PAPAQAAPEI SSTLERIPDK LKEFGNTLED KTRAAIESIK
     QSDIPAKTRN WFSETFKKVK EQLKTAFS