ID   IML1_ASPCL              Reviewed;        1845 AA.
AC   A1CEE0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=ACLA_089310;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; DS027052; EAW11239.1; -; Genomic_DNA.
DR   RefSeq; XP_001272665.1; XM_001272664.1.
DR   AlphaFoldDB; A1CEE0; -.
DR   STRING; 5057.CADACLAP00008309; -.
DR   EnsemblFungi; EAW11239; EAW11239; ACLA_089310.
DR   GeneID; 4705330; -.
DR   KEGG; act:ACLA_089310; -.
DR   VEuPathDB; FungiDB:ACLA_089310; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1845
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301762"
FT   DOMAIN          1344..1419
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          854..982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1425..1483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1825..1845
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        761..775
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        776..805
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..908
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        961..982
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1441..1457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1829..1845
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1845 AA;  207178 MW;  8766A65F8F29E9B0 CRC64;
     MSLRGPMKRS HLRQVSAPSV DDLATSSQAQ AQSHPRDGGP YNDEHGQDFQ STLDARNIRL
     STTSLERRQV SLWVHDETFS REEILFNQAA FSDLGVGPGD VIEILPVRSP GDSLHSIKSD
     LGLRALRDSY VETGPALLPD PMSKFKTPLQ SRCLFVVKPL PQEIKARHPK LEISVTSSVA
     NIFGFKNRTL VHIDVVDRAQ CSASHVDIAF RDQFLVRSDM WRLVMSELAE KIIYKGQKIV
     FMGSIKATVK NIFIREKKVL SGYFSPHTIP VFRSESAKYV LFIQMSREMW DFDSEGTGDI
     LFSRVINGFL PELFKRWANS EAKHLVTIVL FTRVEYDVSA IGAPLPLSSE TLRCISSPNH
     VPTRDFYRVV VNDMASGHWT AILDELKKDF RTFLRDVSTL KMDCADTPTL DGVKVAPKNK
     AATIAGRPST ALRGNILEAI HLASAHLAYD HIDRDMVHTG TSIIVITPGS GVFEVSYESL
     SSTSEALANR GIAIDLVCLS PMPLHSVPLF KYKAPAQRSS SSSFCEFNSS GYSPEMRHSF
     SFASRTPHLS PKSAAHGSFS RGTAHKEHAA SRSDEWNYGI PHWLDISYWN PDTYREARRI
     LKKDLNAPIP FTVTKQSKTF VPRVRMYEIQ MMGVMESEQS NISIPYLLEG EGIHRAPSLS
     LGLSPSALSS TRASYRRNPY KLPLSDSLRP EPFLQGLSNP KDVMLARSKK APKAVLAWME
     QYDDAVFQPF AKRRHQRKPS KPKRLSEPDV QVSGAHERLS ARSVLRLREH ETNANSSERP
     YPTRTIPRVA ETSLSAPQTP VPSKSASPKK PALKPPSAGK APRISRTISF ALRGLSATPP
     RALASTEVNV EHASALPTSS PKLLPGPFPD TRSVDSFSGS DSASISTVID TSLRPASPHK
     TPQSRAIMPS RPISIKVPPR QPSEDAEPGD RAVIPESYST TSTAIPFNEH HRRDSHTRTS
     GPRFEMTVNG GSRDSSIKSP QNKALAPWVR SINPCNTSRE VLRDTSWFGR WQHAYPRPPH
     VAVVKWKSLK SPAILPLTTE EFPTAKELGT DYLQTPYRVF PNDDPEGFEV PKTRGILLRE
     MISLRLSHGF QIVIGKHVAE VSGQHALETL NVFNTASLER NGATIFLSKG NSIHRLVCVD
     GGEIEVTRFT HRTSSALAAG RRDGFSLYSP AMRTILSPEY ELKNIKLDPT AEEYNWNYAD
     NYVAGHRDYL FNPAQQLQFW RVRYVLIPMH LHVNTRRHLQ SFNEDNEEEI HLLGINQLTH
     IWQRHKYIPP EEKRFESSNK KKEQNPLNIM YQTRNPSEVV AAELDRILLS DPGLDSSPAQ
     LLPESELLKR SSISLSSLAH IIQGDKGVRM MDRRWHWRLH YNCFIGFELT TWLLQNFRDI
     DSREEAVDFG NELMKHGLFQ HVEKRHNFRD GNYFYQISSE HRISRPESRG GWFPQKRSDK
     GVPSTPASNN AKDSPLSGHA RSDSLEDGPP HTPATPSKSK NKATIMLSKM MKYDVDPRKR
     SNRPEVIDLH YDRLHNPDNC FHFELSWMNT TPKLIEDTVL SWAATAEKFG LKLVQVPIAE
     ASAISRTQPF RKPYRVSLKI PPPKGPVPTL FNTASFSQPG FTDMHYYHKA MLRKFDFVLD
     FEARSAFPAD VGVSYSWGTP DYQYPQYIHR SGSTLVQLTD EGDFLFLANR LVSTRAAASR
     EMPRYERMDR AEHLRTRAAT HDPLDRLSPR LSPIVRPLHE IGSPQVQSSI DSAHLYRAPE
     LIILGFAEFC NDEGRLEQFY KESHARPVST KVGPATTTLM DSSIPSLELP ASVVSHHLSH
     PPALVARASV DGSISSIDVR VRARNDSVSY KGSPRSGSLR PLNLS