ID   IML1_ASPFU              Reviewed;        1836 AA.
AC   Q4WHH4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=AFUA_2G05390;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000008; EAL87631.1; -; Genomic_DNA.
DR   RefSeq; XP_749669.1; XM_744576.1.
DR   AlphaFoldDB; Q4WHH4; -.
DR   STRING; 746128.CADAFUBP00002189; -.
DR   PRIDE; Q4WHH4; -.
DR   EnsemblFungi; EAL87631; EAL87631; AFUA_2G05390.
DR   GeneID; 3506914; -.
DR   KEGG; afm:AFUA_2G05390; -.
DR   VEuPathDB; FungiDB:Afu2g05390; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   InParanoid; Q4WHH4; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR   GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1836
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301763"
FT   DOMAIN          1337..1412
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          886..975
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1421..1471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1814..1836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        755..769
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        770..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..905
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        927..942
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        954..975
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1434..1471
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1836 AA;  206148 MW;  42A41221F461DBC7 CRC64;
     MALRGPMKRS HLRQVSAPSV DSLSVPQSQS PEALYNDERS HQDVHATPDE RTIRLSSGSL
     ERRQCSLWVH DETFSREEIL FNQAAFSDLN VNVGDVIEIL PVRSPGDSIH SLKSDLGARS
     LRDSYLESGS AHLPDPMSKF KTPLQSRCLF VVKPLPQEIK ARHPKLEISV THSVANIFGF
     KNRTLVNISV VDRGQCSASH VDIAFRDQFL VRSDMWRLVM SELADKIIYK GQKIVFMGSI
     KATVKNIFIR GKKVLSGYFS PHTIPVFRSE SAKYVLFIQM SREMWDFDSE GTGDILFSRV
     INGFLPELFK RWANSDAKHL VTIVLFTRVE YDSSALGGPL PLSSESLRCI SSPNHAPTRD
     FYRVVVNDMA SGHWTTILDE LKKDFRTFLR DVSILKMDRP DTPTVDGVKV APKNKPAIIA
     GRPSTALRGN ILEAIHLASA HLAYDHIDRD LVHTGTSIIV ITPGSGVFEV SYESLSSTSE
     ALADRGIAID LVCLSPMPLH SVPLFKYKAP VERSGSSSFG DFHSTGYSPE MRQSFSFASR
     TPHLSPKSTM QGSFPGMTRK EHLSARSDEW NYGIPHWLDI SYWNPETYRE ARRIAKKDPN
     APIPFTVTKQ SKLFVPRVRM YEIQMMGVME SEQSDISIPY LLEGQGVSRP SNAGLGLGPS
     GLSSRASFRR NSSYKAQLSD SLRPEPFLQN ITNPRDVMLA KAKKTPNQVI AWMDQYDEAV
     FQPFAKRRQQ RKASRPKRPS EPEVQVSNAH ERLSARSVLR LREHETNSNS GDRSYPTRTI
     PRVSETLSVP QGPAPSKAST SPKKPALKAP SAARTPRMSR TISFALLGFG ATPPRAQAST
     EVNVEHARAQ PTSGQKKPSV GFMDTRSVES FSGSDSASIS TVIDTSLRPA SPHPAPQTSA
     MTPTRPISIK VPPRQPSEDT EPVDRTVLPE SYSTTSTAIP FTGDGRRDSR TKNGPSFELT
     VSGGSRESSI KSPQNKALAP WVRSINPCNT SRDVLRDTSW FGRWQHAYPR PPHVAVVKWK
     SLKSPAILPL TTEEFPTAQE LGSDYLQTPY RVFPNDDPEG VEVPKTRGIL LREMISLRLS
     HGFQIVIGKH VAEVSGQPAL ETLNVFDTRS LERDGATVFL SKGNTIHRLI CVDGGEIEVT
     RFTHRTSSTL AAGKRDGFSL YTPAMRTILS TEYELKNIKL DPTAEDYNWN YADNYVAGHR
     DYLFNPAQQL QFWRVRYVLI PMPLQVNNRR HLQSFNEDNE EEIHLLGINQ LTHIWQRHRY
     VPPEEKRFES SNEKKDQNPL NIMYQTRNPS EVVAAELDRI LLSDPGLDNS PAQLLPESEL
     LERSSISLSS LAQIIQGEKG VRMMDRRWHW RLHYNCFIGF EFTTWLLQNF RDIDSREEAV
     QFGNELMKHG LFQHVEKRHN FRDGNYFYQI SSEYRVARPE SRGSWFPQKK PDKQVPSTGA
     SENPRDSAVN GHSRSESVET PATPSKSKNK ATIMLSKMMK YDVDPRKRSN RPEVIDLHYD
     RLHNPDNCFH IELSWMNTTP KLIEDAVLSW AATAEKFGLK LVQVPIAEGC AISRTQPFRK
     PYRVSLAVPP PPGPVPTVFN TATFSQLGSS DRHYYHKALL RKFDFVLDFE ARSAFPADVE
     VSYSWGTPDY QYPQYIHRSG SLLVQITDEG DFLFLANRLV STRLAAATRE GSRYERMDRP
     EHLRARASTH DPLDRISPRL SPLVRPLHDI GSPISPQGQP SIDLAQLYRA PEHILNSFEE
     FCNDAARLEQ FYSVSHARPA STKVGPAPTT VMDSSIPTLE LPASVVSHHI QSPALTTRAS
     VDGSMPSVDA MTRARNDSLS YKGSPKSGSL RPLNIN