ID   IML1_ASPOR              Reviewed;        1824 AA.
AC   Q2UMR9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=AO090001000648;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE57146.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAE57146.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AP007154; BAE57146.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2UMR9; -.
DR   STRING; 510516.Q2UMR9; -.
DR   PRIDE; Q2UMR9; -.
DR   EnsemblFungi; BAE57146; BAE57146; AO090001000648.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1824
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301764"
FT   DOMAIN          1321..1396
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          28..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..964
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1406..1460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1797..1824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        732..765
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..889
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        899..927
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        945..964
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1424..1460
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1809..1824
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1824 AA;  205112 MW;  2A05652CE55611C5 CRC64;
     MSLRGPMKHS HLRQVSAASL ETLSTTRSLA LSQTDGQSDK PSTPDERTIR LSSTGLDRRQ
     CSLWVHDETF SKEEILFNQA AFTDMGVEVG DVIEILPARY PGDGTHSAKT DFGSRSLRDS
     HVESSSTLHS DSMSKFKTPL QSRCLFVVKP LPQDIKTRNP KLELSVTTSI ANIFGFKNRT
     TVHISIVDRA QCAASHVDIS FRDQYMVRSD MWRLVMSELA ERIVYKGQKI VFTGSIKATV
     KNIFIRGKKV LSGFFSPQTI PVFRSESAKY VLFIQMSREM WDFDSEGTGD ILFSRVINGF
     LPELFKRWVN SDARHLVTIV LFTRVEYDAS AIASSTFSSE NLTSMFGPNH VPTRDFYRVV
     VNDMASGHWT TILDELKKDF RTFLRDVSIL NVHNADTPTF NATGASKSQP ATIAGRPSTA
     LRGNILEAIH LASSHLAFDH IDRDMVHTGT SIIVITPGSG VFEVSYESLA STTEALTNRG
     IAIDLVCLSP MPLHSVPLFK YREPAHRPTT AAFGDIQHGG YSPEMRHSFA SISSKTPHLS
     PKSALLDSFT GMSSKSQWSG RSNEWNYGIP HWLDISYWNP ETYRESRRIL KKDPNAPIPF
     TVTKQSKVFV PRVRMYEIQM MGVMESEQSN ISIPYLSEGP NISRATSSTL GSSPGSLVPP
     KATFRRNSPF RHQLSDSLRP EPFLHNMASS KDAMLTIPKK TPKTVLSWMD NYDENVFQPF
     RKRRHRRKPS KIKRPSEPEV KASNAHERIS ARSISRLREN ESTRSASRQI DIPLPAPKSP
     VSTKSASPKK PALKSSSKTK LPRISRTISF ALRGLSSTPP RAQASTEVNV EHARGLPTSN
     SRKLSGVLAD NRSVDSLSAS DSASTVIDLA PSPETPQKPI KNTAITPSRP ISIKVPPKQP
     LQDTEQQGRP AIPESVSTTT TEIALGDDTR LTAQPRRHGP KFEVNLSSGS RNGSSKSPQS
     KALAPWVRSV NPCNTPREVL RDTSWFGRWQ HAYPRPPHVA VVKWKSLKSP AVLPLTTEEF
     PTPSELASDY LQTPYRVFPN EDSEGIEAPK TRGVLLREMI SLRLSHGFQI VVGKNVVEAS
     AQYTLQSPNV FDTHALERAG ATVFLSKGNS IHRLICVEGA EIEVTRYTHR TSSLLASDQK
     RKFTLYSPAM RTILSPEYVV KDIKLDSTYE EYNWNYADNY VAGHRDYLFN PAQQLHFWRV
     RYVLIPMRLH FKSRRLHGFN EDNEEEIHLL GINQLTHIWQ RHKYIPPEEK RFESSNKKRD
     QNPLNIMYQT RNPSEVIAAE LDRIILVDPG LDSSPAQLLP ESELLERSGI SLSSLAQIIQ
     GEKGVRMMDR RWHWRLHYNC FIGFELTTWL LQNFRDIDSR EEAVEFGNEL MKHGLFQHVE
     KRHNFRDGNY FYQISSEYRV SRPESRGSWF PQIRPDKSVP STPVGEASKG SPISGHTRSD
     STEDTQSQTP STPSKLKNKA SITLSKTMKY DVDPRKRSNR PEVIDLHYDR LHNPENCFHI
     ELSWMNTTPK LIEDTVLSWA STAEKFGLKL VQVPIAEACA IDKTQPFRKP YCVQLKAPPP
     KGPIPLQCNS ESFSQPVTLD HQYFHKALLR KFDFVLDFEA RSSYPADVEV SYSWGMPDYQ
     YPQYIHRSGS VLAQITGEGD FLLLANRLVS TRSAASRDMP RHERLDRPDQ YRARAGTYDP
     VDRISPRLSP MARPVHEVHS PLSPQGHASI DSANLYRAPE HILTGFADFC NDPARLEQFY
     SEAQVRATST KVGPAPTTLT DASIPSLELP ASVVSHHISP PPGLPSRSSH NIAAPLSEIR
     RSRDDSNMSR GSPRSGSLRP LSLT