ID   IML1_ASPTN              Reviewed;        1830 AA.
AC   Q0CHV5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=ATEG_06729;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; CH476602; EAU33273.1; -; Genomic_DNA.
DR   RefSeq; XP_001215907.1; XM_001215907.1.
DR   AlphaFoldDB; Q0CHV5; -.
DR   SMR; Q0CHV5; -.
DR   STRING; 341663.Q0CHV5; -.
DR   EnsemblFungi; EAU33273; EAU33273; ATEG_06729.
DR   GeneID; 4322307; -.
DR   VEuPathDB; FungiDB:ATEG_06729; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1830
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301765"
FT   DOMAIN          1317..1392
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          720..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          822..960
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1407..1456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1774..1830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..685
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..810
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        822..890
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        909..927
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        930..944
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1407..1422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1438..1456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1830 AA;  205290 MW;  31F8BD7530F40324 CRC64;
     MSLRGPMKRS HLRQVSAASL DSLSTSRSLE ASHHDAPSDH PSTPDERAIR LSFPGLERRQ
     CTLWVHDETF SREEILFNQT AFSDTGVSAG DVVEILHARH TADGAHSLKA DLGSKSLRDS
     HAKSSSTLHL DALSKFKTPL QSRCLFVVKP LPQDIKTRHP KLELSVTTSI ANIFGFKNRD
     TVYVSIVDRA QCSASHVDIA FRDQYVVRSD MWRLVMSELA DKIVYKGQKI VFMGSIKATV
     KNIFIRGEKV LSGYFSPQTI PVFRSESAKY VLFIQMSREM WDFDSEGTGD ILFSRVINGF
     LPELFKRWAN SDARHLVTIV LFTRVEYDAS TIGMSSTLSP ESLKNIFNSN HAPTRDFYRV
     VVNDMASGHW TTILDELKKD FRTFLRDVST LKVDDAPVAK ANGSASAPNA RPAVIAGRPS
     TALRGNILEA IHLASSHLAY DHIDRDMVHT GTSIIVITPG SGVFEVSYES LASTTEALTN
     RGIAIDLVCL SPMPLHSVPL FKYREPPRRP STSSFGDIQH GGYSPEMRHS FASLANRTPH
     LSPKSAIQDS FPGIGLRDSW STRPQEWNYG IPHWLDISYW NPDTYREARR ILKNDPNAPI
     PFTVTKRSKI FVPRVRMYEI QMMGVMESEQ SNISIPYLLE GQSLSRGPSP GLSLSPASLA
     APGKPSSRRS SNFRHQLSDS LRPEPFLQNM ENPKDVILAK SKKTPNSVLS WMDKYDEKVF
     QPFPKQRQRR RSPKQKRPSE PNVQVSGAHD RISARSISHL RQHETSGPRP AVRKVEPSFP
     TPKSPSSAKS ASPKKPALKT KSTTKVPRIS RTISFALRGL SSTPPRAVAS TEVNVEHATG
     KSSTDTFPDS KSVDSLSVSD SASTRTVIEV SKPPGTPQKP VQSSAITPSR PISIRPAPKL
     PEEPEQPNRS LAASFSTTAT EIPLTEDTRS AAQLRKRGPK FEVTMDPGSR DGQIKSPQSK
     ALAPWVRSIN PCNTPREVLR DTTWFGRWQH AYPRPPHVAV VKWKSLKSPA ILPLTTEEFP
     TATELATEYL QTPYRVFPND DTEGVEAPKT RGVLLREMIS LRLSHGFQIV VGKNVVEVSG
     QYSLQSPNVF DTKGLERDGA TVFLSKGKSI HRLICVEGAE IEVTRFTHRS SSVLSPERTN
     GCTVYTAAMR TILNPVYEIK EIKLDSTTEE YNWNYADNYV AGHRDYLYNP AQQLQFWRVR
     YVLIPMHLRR NIQSFNEDNE EEIHLLGIDH LTHIWQRHKY VPPEEKRFDT SNKKREQNPL
     NIMYQTRNPS EVVAAELDRI LLTDPGLDSS PAQLLPESEL LERSSISLSS LAQIIQGDNG
     VRMMDRRWHW RLHYNCFIGF ELTTWLLQNF RDIDTREEAV EFGDQLMKHG LFQHVEKRHN
     FRDGNYFYQI SSEYRVARPE SRNSWFPQIR TEKSTPSTPA GDHSKESPVV GHARSDSVDD
     TPVQTPTTPS KSKNKATIML SKSMKYDVDP RKRSNRPEVV DLHYDRLHNP DNCFHLELSW
     MNTTAKLIED TVLSWASTAE KFGLKLVQVP IAEACAIDQT QPFRKPYRVQ LKVPPPKAPA
     PTFFNPVSFA QQGAPDQHYF QKALLRKFDF VLDFEARSAF PADVEVSYSW GIPDYRYSQY
     IHRSGSLLAQ ITDEGDILLL ANRLVSTRSA ASRDIPRHER MDRPDQYRAR AATYDPGDRM
     SPRLSPVARP VHDMASPLSP QGHPPLDSAN LYRAPEHILS GIVEFCSDAE KLEQFYDESL
     ARPASTKVGP APATLMDSSI PSLELPASVV SHHISPPPIL PSRGPQGSTT VPSVDLRSQV
     RDDSALPRGS PRAGPRASPL SSGLRPLRLG