IML1_CANAL
ID IML1_CANAL Reviewed; 1462 AA.
AC Q5AIA4; A0A1D8PCS4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Vacuolar membrane-associated protein IML1;
GN Name=IML1; OrderedLocusNames=CAALFM_C102610WA;
GN ORFNames=CaO19.10466, CaO19.2949;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AOW25942.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CP017623; AOW25942.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_721448.2; XM_716355.2.
DR AlphaFoldDB; Q5AIA4; -.
DR STRING; 237561.Q5AIA4; -.
DR PRIDE; Q5AIA4; -.
DR GeneID; 3636813; -.
DR KEGG; cal:CAALFM_C102610WA; -.
DR CGD; CAL0000199259; IML1.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_000935_1_1_1; -.
DR InParanoid; Q5AIA4; -.
DR OrthoDB; 45642at2759; -.
DR PRO; PR:Q5AIA4; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1462
FT /note="Vacuolar membrane-associated protein IML1"
FT /id="PRO_0000301766"
FT DOMAIN 1077..1152
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 168701 MW; 2B0F6841BAE5DE9A CRC64;
MQHPRMFNQT STNAKKPNGS DSSIKVANHS NQRQMSANHA SLTIGGSRNP INQRRSMSTK
NIGSTLIVSR RNNHYLDMKE EDSKENLTKI ISNNQNEEDT EVSVKVSVWF HELRDFTEDI
IIDENVIPTG VQAGQVFELQ SLDEGSSKKF VFTVQKRNLR SATNDTDYTE ASKPKLQISL
MANPFQRLLD LAPRSQVQLK RLVKLESVTV DSVEIFIKDV NLSRDAMWNF SASMIGNCVY
IDQRLLYLGS RVGVTKHIYK NGKNVTSGYV DKNTKIIYRS ESAKITLFVQ LSREMWHFEE
DGEIMFHKLI NNLFPKIFRR WRETNTHHSI TIVLFTSIDL TDIPWTNLGP GQRPPQRRDF
FRVVVDQVNS MHWDRIMEDL RLEFANFKRD TMLNLDDDGK FIIENGTLPA IKGNLLEAVN
LGLTSLNNRF QNTDLKHSIS HIMVITPGTG LFDVEHDLLL ETSKKMSSVD SSLDIICLSQ
PPLHVTPLFR YIKEGKVCHC VPLWCDISFF IDKVQQESQW IPRCKIYELQ MMGVMENEAS
DARIPRLHLN NYGKTLVEIM DEYDSAVFKP IKRIPKPAQV EFKQVKPKFQ APELKNATAT
LSLMFENKPL LQPSNSSTIS LATGTVANPS KDTSALSSLY YINKNSEEIK SPAPSVRSET
PVSTIRAIDS YRKSAGSPRL IRGETMFKRK EEIPNTEPPS ALSEKNAASA RKKSSILAEP
EQEISTGSFW IEISNPSQET TTNVLQRSQS SRWSNIFPNK IQRKLIKWRS FQAPASLPTT
TGVFPSTNQL QTDYTFQIYT VFLNSDNYWE LKSTHSLMRE MIQLRLMLGF QVCYGERVDK
AEAERKPSGN VDAIIKYFPE EHNYLGSRIY LAFGDEIHRI FCDYNGNINV QLYRKIIEND
EKKITLGQTK LKPYFPLIRT RYTDEYTPAR IDAIADNPQK FNWNQFDQLL AGFDDAMPEE
KKQFHKMKFV VMPTDIPKNA YFVSNEKLTP EEIRVEGLRK LIGVIERGKY KHDSSQKKKS
RRGSDVIFYT GNLYDFLNEE AQNYDITGTQ PALMIPESSR FNKTIKLPDL AQELQDRNTG
LTLVDRTWHF KRHLHCFVGS ELVSWLVDCF EDIETREDAT TYGQNLMNKG LFKHVESRHG
LLDGHFFYEF SDEYVDKTDR EKPSWFGSKK IDGASTPQSN SSPRIAGQND LQKIISASNL
RSETSSTTDS MGRKRKKFIL SRSVKFDVDP LKKSFRPEFV TVHYDRVHNP EHCYHIRLQW
LNATTKFIED TITAWTRLCE RHGLKLVETP WNELCSLPKL SPFHSFVDIK LSVNPWTDPD
LCDDRILSSN RYYYHSYFLK QMGYYLDNRS TSFFSRENID IGYSWGKPTF RYAQFIHKTG
FYIVELRDNG DFFLAPNNMH LTRVRSSTTL VGDYENYSKG VLADSQTVML NFRAACQNKE
FLKETFTLAK SNWKDDYFSQ II
