IML1_CANGA
ID IML1_CANGA Reviewed; 1804 AA.
AC Q6FK84;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Vacuolar membrane-associated protein IML1;
GN Name=IML1; OrderedLocusNames=CAGL0M00352g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR380959; CAG62336.1; -; Genomic_DNA.
DR RefSeq; XP_449360.1; XM_449360.1.
DR AlphaFoldDB; Q6FK84; -.
DR STRING; 5478.XP_449360.1; -.
DR EnsemblFungi; CAG62336; CAG62336; CAGL0M00352g.
DR GeneID; 2891143; -.
DR KEGG; cgr:CAGL0M00352g; -.
DR CGD; CAL0137411; CAGL0M00352g.
DR VEuPathDB; FungiDB:CAGL0M00352g; -.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_000935_1_1_1; -.
DR InParanoid; Q6FK84; -.
DR OMA; RMYDLQM; -.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR GO; GO:1990130; C:GATOR1 complex; IEA:EnsemblFungi.
DR GO; GO:0005096; F:GTPase activator activity; IEA:EnsemblFungi.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:EnsemblFungi.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:EnsemblFungi.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IEA:EnsemblFungi.
DR GO; GO:2000785; P:regulation of autophagosome assembly; IEA:EnsemblFungi.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1804
FT /note="Vacuolar membrane-associated protein IML1"
FT /id="PRO_0000301767"
FT DOMAIN 1414..1489
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1804 AA; 207409 MW; 1367FEE9FCEDCDEB CRC64;
MFSALRSKNQ SNKRSNDDSI NSRKDVNELS LGAGGTSTST NTNHNDSPSI KNKNKNKNKN
KTENENIYKL TISSGRSRGT ASNTTNANTL VLNAGVAIVG KAPIASSQNE IQTISGQSLQ
SGIDTNLMTA GFGRSAGIDS TTTVSHDANS VKSRLQRLPT ITTSYKEINN GNKPVQVEPQ
DDSHYTSSLL VDTDPRSNNQ PQSISSNAVA NVEINRTLQL DLVYHESRVS EKLVMLDLKK
LPHIKEGQLC ELRTYRKRKS TSARSNKNSR DKKLYFIAHD FDEETRKRCH KFGNISVALG
QLQLLLDLPP RSRVWIKPKR KEDTAADLIE LHIKDILVNR GDMWCMSSEL VDTCVFTGQR
IMFLDSIRTT VNGIYKNGKK VLSGYINDNT KIVFRSESSR LLFIIQITNE MWSFDESGEQ
MFQKMINSFF PKIFNKWKDI ETHHSITIAF AISMDMSTSS YKDLKPGQRI KNTTDYYRIV
VDQVSVIYWV EIMESLRKEF MEITRELLSR KSDDKKDNEL SVIKGRFAPV IKSNILELIN
FAATTIVDPF RQLDLRHTST HVMIISPGKG LYDVDYDLLQ LSCKKLLSLE LTMDLICLSN
PPLHVVPLFR YIDYENKLHH CIPPWLNIFF WNDKTKDTNK WTPRCQIYDL QMMGLTDTEL
VQELELDYLN PSDDINDLQT FLKDYDRDIF LPISTANFKA ENISSDPDEE DLKELKKIND
KTTTIHKSST SRNTLTKSQR TNSEENNSIR SRKGDTIIKD PQFVGKISNS SRNNPPYDLS
DKSTFEKQFK PKTTFHPSAM IKKTPENMKK LTNPVFQQQY FDIQTDNGLT GNSKNLLIKN
TKYLTPIIDE PQTPLVTGNL YRTRFESQSN DNELNENSKL PERGGGTDER RNVSAADTLK
DVTKKSSIKD FTQRIFTKFL ATTKQSNFNS DGINSSAITE DAVLISDDTD GKTNNNNDFA
VYPSSVADGD VSGDNQHRLN NKDSFTSILK PIPRPQLGVK IFKSDINNLS SNENVNSETK
QNLLGTRNTI NRKQFTASPH FTSSTKNSVS NHSRFIKFDS MDDWIEILED SIPSYSFLGD
DLLPTRWRDV WPKNVFRKYS KWKSFTSPAE LPITLKRFPS KYELENNFML RNHSVTQNWE
QEQYKLTTKD LLRNMIYLRL LVGFQICTSS TIEEVESARK GDRDVFAIHK YLRGDLTGTF
KIYMLMGSEI HRLHYDNSGT INVERYIEKS ERNVFDQVPS YTSFVKTRYD SNYRKTDVDP
IHTKRSEFNW NLLDQLLAGY SDPYLYDEWH GFRSKYVILP AEIPSNTFSM VVNGKNETLT
TEEIRVEGLR KLIASITRLK LLSVEESKIQ KDRKTEIQPE VIFYTGSLFD FLNEQQAQLD
SSTLNFKDSI FGDVTKKLNK NIDLKNLAQE LQMGENKLNL VTRKWHWKRH ANCFVGSEMV
NWLIRNFSDI DTRSTAISYG QKLMNDGLFI HVLDKHSFLD GNYFYQISPE FIINMNTVER
TNSKNSNTSD NNTLKKTTSR NSTESNLTPL SMRNKVSTMD DDSTQLANTT SANSYKEKKT
VVLSNSMLIN VDPSSKSYKE ELCTVHFDRV HNPEHCFHIR LEWLTTTPKL IDNMLGNWAR
ICEKYGLKLI EIPWNELCTI PSVDPFHTFV QLHLVINPWE DPEFNDPELF AVSKFYYHIH
LLKMSGFLLD NRASRFFQRD DADFEIMYSW GKPQFKYAQY IHTTGAYIAE MRENGNIFLA
PNNVYMSRVN RANVISKTRS SPTFTVDSRK VVIEFSRTCY SYAKLRAVFL DAKEKWLSNK
TVED
