ID   IML1_CHAGB              Reviewed;        1889 AA.
AC   Q2H0S0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; ORFNames=CHGG_04626;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; CH408032; EAQ88007.1; -; Genomic_DNA.
DR   RefSeq; XP_001223840.1; XM_001223839.1.
DR   AlphaFoldDB; Q2H0S0; -.
DR   STRING; 38033.XP_001223840.1; -.
DR   PRIDE; Q2H0S0; -.
DR   EnsemblFungi; EAQ88007; EAQ88007; CHGG_04626.
DR   GeneID; 4392909; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_0_0_1; -.
DR   InParanoid; Q2H0S0; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1889
FT                   /note="Vacuolar membrane-associated protein IML1"
FT                   /id="PRO_0000301768"
FT   DOMAIN          1331..1417
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          716..808
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          838..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1252..1272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1424..1484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1724..1824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..540
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        716..741
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        781..801
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        838..883
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1738..1824
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1889 AA;  211950 MW;  F562424015EA384C CRC64;
     MPPPPRNSSS ASLSATPGLA KGPNNNWPTH LRHFRRSSHD RSLEHAYSNS PGDTVSSNST
     IRERPSSRLS SRLRTERRWT VTVNESLARD EVLLNLDLIG DDIQPGSLVA IDVVKADSEK
     PLQNSHPRHF QDRKDSATAG CVERRYICVA KDMPKELKAR YASVEVYVAK HVADAFAMRK
     GTQVTLTPID ENNPALEASH VELCFKDQYL SRADMWRMAV GELAERTVYK GQMVLFMGTV
     KAQVTAVYVD GRKAQSAFFG RHTKPVFRSE SARYVLFIQM AREMWDFDQD GSGEIMFNKV
     VNGFLPALFK KWAAMKVKHL VTIVLFARVE YDTGISTELA SASAHHGYYT GVQASEDQRP
     YKDFYRVVVS EMGSGEWTRI LHQLKREFNY FRKDISTYHQ KAMEPTNSGE DSGEQEVLLN
     RIKAEASRAI HGNFLEAINM ASSLYAHDYI DRDLTRTGVS VVVISPSPGV FEVEYDALRR
     TTEALACNGI GIDLICIPNI PLHSVPLFRY RNPRQPGQVQ RKSKVDISQG STPKQTTLTF
     GSYSSLAGSY SPNKRIEGSR NGEPAGPLSS QEEWVSAIPQ WLHVSYWTGA SEEELSYQGI
     ALSVSDATQK LPSDEFPIRC RMYDLQMRSV METNEIETKP LHTDPCYPLN AVLASQISKP
     HFDLDNDGNV IIPNARVPET LFDHVFGFQK FAPDRHRKPG EKSIWRQLQE YDDCRARLPS
     HRNANQTRRC RDHEETPRRQ ALEDTSPLGT SYTDRRPSTA SQQTLPELSP YHRPTSQRLE
     VPPVNRKSMS AQSNKSEPKA SSSPLKAPKF MRHISLGNRG FGIAAPKVAT AEVSMESAGA
     SKTLTPSRSS QDLRVTPSKP GQRPSSSRRL TGGTSTSALS PALSPFSFAP GPQFPTDSPT
     RPIVIRNQQL EPAAMLSGSS ILATTLRPEP VGHDRDFRYS NAIRAEDAKK LYNSKLLAGA
     IPELPSTLSP KTALSPWLTV LNPSNPDTND VDMAMLYSRW QHVFPRPQEM RIMKWKGLCS
     PAAVPLTSEY FPSRDQFEAQ YERQPYNVSQ DFDEELQEEP KSRDELLREL VSLRFSQGFQ
     IVVGPAVAKA FGQKQVKVAD IFSRNHMMED GISIFMSVGN TIHQLSCVNG TEVEVNIFVR
     KPTDSFGPSF SSPTLYKPAI RTLLDGGYRT SEFDLVAPKA ERNWNYIDAF IAGHNDELTE
     HLRFWRARFV LIPMTGRRSS MPGTETGDNE EEIRIEGIRK LAQMWQKHRY VPPNERRLQG
     SGSTRSKKDT NPLDIVYKTE DASVVIAAEL ETLPLLEGLD RKGQLVRNRE PFSKKNINLA
     ALAEAMQQPV ENGGVRMQNR RWHFRLHYNC FIGSDMTSWL LDNFDDLEDR EEAEALGKRL
     MVPDDKEKEG KKDSGLFVHV EKRHQFRDGQ YFYQISNEFA KPHPPGWFNA KRGQGSMPST
     PMGEQPPRDG RPSFSRPTSI HEEDSPESGE TTPTAPQAPA GNKPKVVLSR VIKYDVDHRK
     RSYRPEMVEL HYDRLHNPDN CYHLRIDWMN VTVQKLVEDV IENWAREAGQ YGLRLVEVPI
     AEASAISEIN PFRRPYKIKL AVPPPDQSPV TYYDPTSFTP QAHPGRQFYQ KAILRRFDFV
     LDMEAASNFP SNVDVSYSWG RPDFRYTQYI HRSGSILAEI TDDGHFLVLA NRLYSSRAFA
     AREREMQKEL RVERQEQGPA IGTPGLGSSI RVITPSSYTP YNIPTPLPPY DSSPVASPAL
     RPVTTTTTAT TTTAAPTSSS LLSPVVRPTL SAPGTTPGST SASGTPGLTH TPNQGQPGKP
     PSTSATTTTA CAGGGGPGSG WSTWTTREPE WIKDELENFC LDAAALEAFY RELRTAARAT
     TSAGRCGHDA GFWCGWRWCW CWGWAREWD