ID   IML1_COCIM              Reviewed;        1857 AA.
AC   Q1E9Q9; J3KHP3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; ORFNames=CIMG_00704;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS35350.3; -; Genomic_DNA.
DR   RefSeq; XP_001246933.2; XM_001246932.2.
DR   AlphaFoldDB; Q1E9Q9; -.
DR   STRING; 246410.Q1E9Q9; -.
DR   PRIDE; Q1E9Q9; -.
DR   EnsemblFungi; EAS35350; EAS35350; CIMG_00704.
DR   GeneID; 4565744; -.
DR   KEGG; cim:CIMG_00704; -.
DR   VEuPathDB; FungiDB:CIMG_00704; -.
DR   InParanoid; Q1E9Q9; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1857
FT                   /note="Vacuolar membrane-associated protein IML1"
FT                   /id="PRO_0000301769"
FT   DOMAIN          1338..1413
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          799..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          833..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1426..1496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1711..1730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..759
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..886
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1450..1464
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1714..1730
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1857 AA;  207466 MW;  DA67AA83F20FCF08 CRC64;
     MLQSGGIKGP QRKQFQPASA EARSMRATIA SLQDSKVDSA RPDSPQYSPK SPSKRSCTLW
     VHDETFSREE VLCNLQALPD FGLNVGYLVE VSVAQGDHLG SQLKPEAGSR YLQDEGSFTS
     PRWPIGAGGS ASRSTFGGDA KLRSRKTPGK FLFIVKPFPP EVRAKHPNLQ VSVANHVANA
     FGFKNRSQIH LTVRKRAQCS ASHVELIFRD QFLLRSDMWR LTMSELVDRP IYKGQKILFM
     GSIKATVKSV YISGNKTLSA YFSPNTIPIF RSESARFVLF IQMSKEMWDF DSEGTGDILF
     SRVINSLMPE LFKRWANIDA HHLVTIVLFT RVQYDFATPT SGPATLNSSF LNRGPDGSAP
     KTQDFYRVVV NDMPSGQWTT ILDSLKKEFR TFLRDVSIPP PYFPDTPIAA EDIPRFTESH
     PPKIAGRPTS ALRGNILEAI HVASSYLAFE HIGRDLVRTG TSIVIITPGT GVFEVPFKIL
     SLTSDVLTSR AIGIDLICLS PMPLHSVPLF KYKLPRDTSC RPGSSISSRL APYEHRRMSA
     TFSTAHMSPL DRPGTALSDQ ALQGIGSSPQ EEEWGYGIPH WVDISYWDPK LDRASRAAAK
     KKTTMSPVIA TIAKNSQLFV PKVRMYEIQM MGVMESEQSN ISIPHMSSTS SRTQKRPGTL
     ASLAASIGNS PSPDSSYRSQ AGDGFRPKSF MYNIKDSKKS MLPPDAKERT NLVEWMDSYD
     QSIFHLHPKQ KRPRRRSKAK QAAETETSRP SQHETPKLRS SMDLGQPDNR HLSPFGQPHL
     QLRYERIEEE SLVTPRRITQ PPTQTNMKSI MKPKPKLPIP RISRSISFAL RGLGSAPPRA
     HASTEVKTEH AQALPTSGGR TPEDPASEAS NTVTPRQNSP LNSGAATPKP ERSEADAPSN
     VEAMTPSKPI LIRAIRRTGE DGSVEPLPLE GSFSTQGTEP RHDLLQHHDS QGAFPVKRTG
     RRLDLLSSGD PTSPPTVSAT DALSPWVSPI NPWNPPKLAP SRSSWYGRWQ HVYPRIPKTT
     SVKWKSLKSP ASLPITAEEL PTESELTSNF LQTPYRVYQN DEADAEVPKT REMLLRDMIS
     LRLSHGFQIV VGKKVEEQST GYSNIFDTNA LSKDGTTVFM ARGNVIHRLV CVEGEIEVTK
     FTRRPLNGFP TDELNDASIS YSPAVKTILS AQYCKNTISL GAPPEEYNWN SADAFLAGHR
     DHITNSIRQL RFWRTRFVLI PVQVPLAARR HISSFHEDNE EEIHLLGIYK LTQMWQRHRY
     IPPEERQFQS AARKSKDQNP LNIIYQTSDP SVVVAAELDR LLLEDPGLDN APAQLLPDSE
     LLQRYNITLA FLAQKIQGEK GVRMMDRRWH WRLHYNCFVG MEFTTWLLQN FRDIDTREEA
     VEFGNDLMTH GLFHHVQRRH NFRDGNYFYQ IADEYRVVRP ESRGGWFQPR KVDKSNPNTP
     MGEAMKDSAS SIRARAEKSI DETGSKLDIP GSSKPSRPKP SISLAKSLKY DVDPRKRSDR
     PEVIDLHYDR IHNPENCFHI ELSWMNATPK LVEDAIMSWV GTAEKYGLKL VELPISEASS
     IVERQVFRRP YPIKLKVDPP PTPVSTYLTA TSFTSQAVPD HHFYQKAILK KFDFVLDFEA
     KSAFPANVDV CYSWGKPDYQ FPQYVHRTGA VLAQITDEGH FLLLANRFHN SHNPVSLKDS
     NKFDRSSEYF PRPRAATFDP LDRRSPLLSP VARPTPGTDS SIPSASPPYI SASDASQNSY
     RVTDQIKDSM RAFCSDAEQL EAFFAEMAMA KGKTATTAGP ASLSSVKLSP TTPATVDSSI
     PSLELPASVV ARNLHLPQPV ALAAAQASAE TPQVAGSIDA VMRSTSVSSP RNGAFRH