ID   IML1_CRYNB              Reviewed;        1768 AA.
AC   P0CO33; Q55V51; Q5KL31;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; OrderedLocusNames=CNBC6320;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; AAEY01000017; EAL21594.1; -; Genomic_DNA.
DR   RefSeq; XP_776241.1; XM_771148.1.
DR   AlphaFoldDB; P0CO33; -.
DR   EnsemblFungi; AAW42101; AAW42101; CNC00940.
DR   EnsemblFungi; EAL21594; EAL21594; CNBC6320.
DR   GeneID; 4935299; -.
DR   KEGG; cnb:CNBC6320; -.
DR   VEuPathDB; FungiDB:CNBC6320; -.
DR   HOGENOM; CLU_000935_1_0_1; -.
DR   Proteomes; UP000001435; Chromosome 3.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Vacuole.
FT   CHAIN           1..1768
FT                   /note="Vacuolar membrane-associated protein IML1"
FT                   /id="PRO_0000410121"
FT   DOMAIN          1326..1402
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          86..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          637..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..934
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1419..1439
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1457..1476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1729..1768
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..670
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..737
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..792
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..816
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..865
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        876..893
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1768 AA;  197541 MW;  16B1F4BE31D4A0CD CRC64;
     MEGGVLDLSL LNKDRDNVAL LLYTYKPLLN NTGASANPAH PSLLPSAAAS PNAPSSQVII
     NYAALPWNVQ PGDYLEIRQI NRTQPKVPTA STRIQGMEGE KPQKIKRPPA LEDVKTGKGR
     EGYVFRLGED SPTANIHQIQ VPDSVATAFG FQNRLEVEVR RIHDKESSHA DYIEFYFSQY
     LGRADMWRLG MSLEGTTLHV GEKVSLAGGA VRAEVNFIIR DEKSKDGIAK PKRYSSGIVT
     AKTKTIFRSK SAQVYLFIQL CEETWQFDED GERYVEKVVH GYLPELFARW ADKGTSHVVT
     IIFFARIFYR DDEVDYLRKH DMVDMLSQDY SGQWYKDFFK VAVDLERRND WMSSLPEIKR
     QLERSEREIL LDYHLRLLKA KGAAEEEIKI VGKWCFAYQG NVLEAINLAL NPFDEHYVDR
     DLSRTGLSIT VVTPGTGHFA VDKNLLRLTT ERMVDHGMSV DFVCLTKMPL HSVPLFSYVS
     HRPKGPVQHE DGIGAKAKPV VPDLLYFDAN LSQVKDIELA DCYSLPSWVS TSFYAVTHDK
     PFREDRFVAR CKMYDIQMLG ILDHNLTTVT VPLLNVDDTP MPRRPLTVDD RKAIRDSFDQ
     SIFSGISDLV KTGSSPLDSA PASVTASYQS ARLLAEKAKE RTSSMSLSKP RGSDIANSSR
     LSPIKATSES DNIDLGKKTT PRSPSPEPSS LSLRRGSRRS LSPTKMTQLA HTSAVTNELN
     KDSPSLLKNS RPGSPITMAR SISPVPPLPP TREQGDSPLS PVDSLPLSAS VERSPSPSRR
     SVRSNMTDRE HLGSGASTPK GTPAKSLRSQ PSKGFIPSWV LNSFKPLLST SKPSFAVPAM
     ENVARTDVAT GDDNRPSSPS PSVGSLRGRP SKGGPNPKPI ITPSTPSPSR SQKPPFKPAK
     IIQTQPHTQA QGTQPLPIAA PPASRLPSQS EEDAISRSFR NKGHGLSRSH EDSSLRAQSN
     ALVQSSRHFT INPCKPSAET IDRVRDAGGR RWRFVLPKLT QQHIVQWPSL IAPACLPLTT
     DFLPDQKQSD ELYTTGTYTV QCYLEDDQFL IRSDAAETNL ALAMMREMVS QRLSQNFQVI
     VQPHELTEPE KPRPMPIHLE KDADIGVELV SGGASEVLKK GQGAIWLSWA NHIHRLLFHP
     TKPEIVVHWM TRKITHQTES VQWKGLVWPS GMKGYQKASA TFAYPDVSMK INYNHLDHLI
     NGERIDFAPL RYWRTRFILI PSGREPVTFP GLMPKNENLG SNDLLWLGAQ KVMETLNRYL
     LKRPEGTPQQ RSLKIVATTF DPSTCVLDEE LMMDLARQIH GDSSGDKKKK LEGMTLANVA
     ELMCQPDNGL VIRTRWWESR QHVSSFNGFE LREWLQNTFE DVTGREKAQE WAAELTNKGL
     IEHVTKSHGF LDYWHLYYRL REPYNHMYSH LAKKEGKNKS WFSTSSKGSR AAPPSLTSSQ
     ASSSTVIAAA VADPSQATAD LNTSQSGKDP SAGEQDQSSL AKIYLKVHKG EPKQGGKKRK
     IMMTQKRVLD LDPSRKSDRA EVAILHADVV HNARNAFHFE LNWLGVTAAL LEELRQKLSA
     QSERYGLRFV ETPVEQIADI PKKCAYRTPI PIRLALAPPV IPDLHTRLVA VAHGTGQAEN
     YFEYSILTKK FGFVLDVEAT DRYPDNVEVV YSYRKAGVKY TYSQFCHKTG LALVQCVGGE
     AGFLWSDNRL VVSAPTRKGV GNRVDEARAL RKELEDFCSD AEQLSKFYEE VLPPPPTTGE
     STPEEGQEEF EAKDDEEEQP APQEKTEL