IML1_DEBHA
ID IML1_DEBHA Reviewed; 1560 AA.
AC Q6BN00;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Vacuolar membrane-associated protein IML1;
GN Name=IML1; OrderedLocusNames=DEHA2F01320g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR EMBL; CR382138; CAG88724.2; -; Genomic_DNA.
DR RefSeq; XP_460420.2; XM_460420.1.
DR AlphaFoldDB; Q6BN00; -.
DR STRING; 4959.XP_460420.2; -.
DR PRIDE; Q6BN00; -.
DR EnsemblFungi; CAG88724; CAG88724; DEHA2F01320g.
DR GeneID; 2903820; -.
DR KEGG; dha:DEHA2F01320g; -.
DR VEuPathDB; FungiDB:DEHA2F01320g; -.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_000935_1_1_1; -.
DR InParanoid; Q6BN00; -.
DR OMA; REMWHFE; -.
DR OrthoDB; 45642at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1560
FT /note="Vacuolar membrane-associated protein IML1"
FT /id="PRO_0000301771"
FT DOMAIN 1147..1222
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1560 AA; 179600 MW; 8DBE9C7980273C85 CRC64;
MHDARIFNSS SNKTMNQNDE AGKSKIKPLR TNQRRVIGAS KSSSHMGSHV GTTLIIGKNS
HSTSHGVRNN SPENTIVIGR RNFSDGQIEY TKPASHSNKF KKDSILRDPN IDSNVEASKK
LSEQIQLTVW FHEPRTSTED VIIDASVIPG LKEGDICELV PLNTFKPHKK PKRLIFIIKN
QSLLSKSSSL HTSNNNNNAG ATTSTLSANN NNTTKTKTNF QISLISNPLQ NLMDLPPRSL
VQLKTILDVE SIEADTIEIF IKDINLSRDL MWTFSSSLVG TCVYSEKRLT FLSNRTGVVK
KIYKNGNELF SALICEKTKV VFRSKSAKLV FLVQLSREMW HFEETGEIMF HKLVNTLFPK
IFKKWRDKNT HHAITIVLFT SVDLTNIPWT SLGQGERPNN RRDYFRVVVD QVSIFHWDRI
MANLRLEFAN FKRDIMLNCQ PENNGKFTMA GQSLPSVKGN VLEAINVGIH LVNDRFKNTD
LKHSLNHFIL VTPGTGLFDV DYSLMHETSK KMLSIDCALD IVCLSQPPLH IVPLFRYRDP
SKDGQISHCV PHWCDISFYK DSTANSTQWI PHCKIYELQM MGVMENEIND VKIERYRVPN
EAKSMVEAMD KYDSDVFKPV NKDSDSKVTR ELSSSPEQST INSKTGTPKE NSKPLSLIWN
NRTSLLPNSS TARIDVSTTN SSVLGTVANS GKDVSALSSL YTLNKTSADK SVVHAPSIRA
DSRKGVKENV SRDRKEFNEI TRTKLRPRLQ KTEEFYKSDD SVSNTSKSRD ILDSKSRNKQ
SSTKVEEEFE TLTNLLWTEI RNPSKESHSD MLSFLRLSRW NDIFPSNIKR RLVKWRSFES
PAALPVTTSI FPSTKQLETD YSFQIYSVFL NSENDLEIES THDLMREMIQ LRLLLGFQIC
YSDQVKKFES SRKPGGNAES LIKYFPKGSC YGSRIYMSLD DEIHRISCDY NGNLYVQMYR
KIEELKHSRL LGSKDYRQQS YVPLIRTRYV DEYAPAKFDF INTKPLKYNW NQFDQLIAGY
DDAIPPEKRQ FHKMKFVVLP ANIPKNAYFI SNENLTDEEI RVEGLRKLIG LIERGKFVKS
DDKESKRKEE ILPEISFYTG NLYEFLSDQA ETYDATGNEP SNSLMLGENM RFTKSIKLSQ
LAQELQSPTG VRLVDRTWHF KRHLHCFLGN ELVSWFIECF EDIDNRNDAT SYGQSLMDRG
MIKHVESRHG FLDGYYFYTF EGEYIDKNYK PERLNSGWFN RKKNSSEKGS AVTSPTYTRN
NSDTESAKSP VFPVQDNLDL RKITSNSIGQ HMYDSETSSM AGSSTKTKQK KKFILSRSVK
FNADPLKKSF RPEIVTVHYD RVHNPEHCYH IRLQWLNTTK KFIDDAILNW SRLCERHGLK
LVETPWLELC TIPQVNPFHS FVDLKLVINP WTDPEFSDPN ILKDNKFYYH LYLMKKSDFL
LDNRSTVFFS KDHIEISYSW GKPIFQYAQY IHKTGAYIVE LRDNGDLFLA PNNIHITRLN
TSLSSVPEQD YLKSYKMDSQ KVMLKFRSAC TNEKILRGIF KEAKENWREK CSEVVLPAIN
