IML1_EMENI
ID IML1_EMENI Reviewed; 1831 AA.
AC Q5AW24; C8VBI8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Vacuolar membrane-associated protein iml1;
GN Name=iml1; ORFNames=AN7506;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR EMBL; AACD01000129; EAA62086.1; -; Genomic_DNA.
DR EMBL; BN001304; CBF79520.1; -; Genomic_DNA.
DR RefSeq; XP_680775.1; XM_675683.1.
DR AlphaFoldDB; Q5AW24; -.
DR STRING; 162425.CADANIAP00000605; -.
DR PRIDE; Q5AW24; -.
DR EnsemblFungi; CBF79520; CBF79520; ANIA_07506.
DR EnsemblFungi; EAA62086; EAA62086; AN7506.2.
DR GeneID; 2869353; -.
DR KEGG; ani:AN7506.2; -.
DR VEuPathDB; FungiDB:AN7506; -.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_000935_1_1_1; -.
DR InParanoid; Q5AW24; -.
DR OMA; RMYDLQM; -.
DR OrthoDB; 45642at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1831
FT /note="Vacuolar membrane-associated protein iml1"
FT /id="PRO_0000301772"
FT DOMAIN 1324..1399
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 31..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1772..1831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1831 AA; 205618 MW; D28945C4E8C73837 CRC64;
MSMRGSMRRS HLRQVSAASL DSVSSRSVDT AQHDALQLSD HPSSSDGKTY KFSSTGLDRR
QCSLWVHDET FSKEEILFNQ AAFADTGVRD GDLIEILSAR TVVDGPSSGQ SQSHSFNLAV
KPDMRTRSMR DVHGHGHSHV ETASSSRSHA MSKFKTPLQT RCLFIAKPLP NEIRTKHPKL
ELSVTSSVAN IFGFKNRSTV YISIVEQTQC AASHVDISFR DQFLVRSDMW RLVMSELAGK
IVYKGQKIVF MGSIKATVKN IFIRGKKVLS GFFSPQTIPV FRSESAKYVL FIQMSREMWD
FDSEGTGDIL FSRVINGFLP ELFKRWANAD ARHLVTIVLF TRVEYDASIT GLPSTLNSEN
LKNTSEPNHA PTRDFYRVVV NDMASGHWTT ILDELKKDFR TFLRDVSILK VPEDPVASTS
ASTTPKATIG GRPSTALRGN ILEAIHLASS HLAFDHIDRD MVHTGTSIIV ITPGSGVFEV
SYESLASTTE ALTNRGIAID LVCLSPMPLH SVPLFKYREP NRGGRSSFSY GGDIQGGGYS
PEMRHPFASL TNRTHFSPKS TFSSTSPASG PRGPWTRAND WSYGIPHWLD ISYWNPETYR
ESRRILKKDP NAPIPFTVTK KSKLFKSRVR MYEIQMGGVM ESEQSNISIP YLLEDQITSR
SLNVPPKTSF RRNSHFNHQL SDSLRPGSFL GNMTNPKETI LSRSRSASAT AAWMDNYDDN
VFRSFSKRNH RRKQTKPKRP SEPEVQVSTT HDRLSARSIT HLREHETKPN EWPRKEAAPK
IPATKAVSPR KPALKAPSKT KVPRISRTIS FALRGLGVAP PRAQASTEVN VEHATGLPSS
NTKRSAGSLR ESKSIESLSA ASDSTSTATV VEASPMPSTP PRQRKSPTIT PSRPISIRVP
LKTPIEDSDQ PTRSVAESFG TNGADLPITE KASLEHQTRK SIPRFELTTS PGLRESSAKN
LQSRLLAPWV RSINPCNTPR EVSRDTSWFG RWQHAYPRPP HVAVVKWKSL KSPAVLPLTT
EEFPTASELA SDYLQTPYRV FPNDDAEGIE APKTTGLLMR EMISLRLSHG FQIVVGNNVV
EASGRYALRS PNVFDTQTLE MDGATVFLSK GHSIHRLVCT GGNEIEVTRF VHRSLSDLVS
EKKNGLDIVY SLAMRTIMSR EYDIKHINLR SSAEEYNWNY ADNYIAGHRD YLFNPAQQLH
FWRVRFVLIP VRLHVHARRH MQPINEDNEE EIHLLGINQL TLIWQRHKYV PPEEKRIETS
SKSRDQNPLN ILYQTRNPSE VVAAELNLLA DPGLESSPAQ LLPESELLER SSISLSSLAQ
IVQSDKGVRM MDRRWHWRLH YNCFIGSEFT TWLCQNFRDI ETREEAVEFG NKLLELNLFQ
HVEQRHKFRD GNYFYQISSE YRVARPESRN SWFPQIRPDK SIPSTPATAD NWKDSPLSAH
SRSASVDQNA PQTPTTPSRS KSKASVMLSK TLKYDVDPRK RSNRPEVIDL HYDRLHNPDN
CFHIELSWMN TTPKLIEDTV QSWAATAEKF GLKLVQVPIA EASAIDQTQP FRQPYRVKLK
VPPPKGPSST IFNAASFSQQ DAPDPHYFQK LILKKFDFVL DFEARSAFPP DVEVGYSWGR
PDYRYSQYIH QSGTLLVQIT DEGDFLVLAN RLVSTRTVPF TGTRDRDHRA RAGYDPMGTI
ERDRLSPRLS PLVRPIHDIA GPASPMAHSS LDSASLYRAP EHVLHGFEEF CNDPVRLGQL
YSESFVYPVS AKAAPTTASC VDSSIPSLEL PAPVIGHHIS PPPGTPVRPE TRTRAASTSA
NGSLPLIDPR SRQREESSVA RGSPRSASIM L
