ID   IML1_KLULA              Reviewed;        1558 AA.
AC   Q6CWI2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; OrderedLocusNames=KLLA0B03894g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02100.1; -; Genomic_DNA.
DR   RefSeq; XP_451707.1; XM_451707.1.
DR   AlphaFoldDB; Q6CWI2; -.
DR   STRING; 28985.XP_451707.1; -.
DR   PRIDE; Q6CWI2; -.
DR   EnsemblFungi; CAH02100; CAH02100; KLLA0_B03894g.
DR   GeneID; 2897535; -.
DR   KEGG; kla:KLLA0_B03894g; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   InParanoid; Q6CWI2; -.
DR   OMA; RMYDLQM; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:EnsemblFungi.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:EnsemblFungi.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:EnsemblFungi.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:2000785; P:regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1558
FT                   /note="Vacuolar membrane-associated protein IML1"
FT                   /id="PRO_0000301773"
FT   DOMAIN          1163..1238
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          9..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1258..1294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        717..748
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1261..1289
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1558 AA;  179385 MW;  5BB954D89B1750E7 CRC64;
     MPPGELIFSN LRSGSRPVPR DRDALSSVQS DAISTKSSAR YNFQGTGSSD ATSGTNVTIR
     NNTLSIGVSS QMQGSAFNGP RMQLSTNGLK NTQSKALQAQ SQDGCQDSKN IADNDSDAEA
     RTAKRSLELE LAFHEARFSN EQVMVDISSI KGAKEGDLAE LKTYRTSPGS KDKKLYFIVK
     DFDTETRRRL KSFQISVLSG QLQQVLDLPI RSKVWVKLKE KKQLAVDLVE LHVKDSYVNR
     GDMWKFSTQL HDSCVFLGQR VGLIETVRAT VKGIYINGKK IFSGYIDENT KIVFRSESAK
     LLFMIQITDE MWHFEENGEE TFHKVVNSLF PKIFRKWKNI GTHHSISIMF CASIDRSDSS
     FNDVTSGERL KNTDDYYRAV VDQVNIVHWV EIMKTLRKEF IRIAQDLRNV KLNENVSVIK
     GSLPSVIKSN LLETINLATT LVTDPFKQND LRHTTTHAII VTAGSGLYDV DYDLLKITTQ
     KLMSLEITMD LICLSRPPLH IVPLLRYRDY KDQLHYCTPT WLSISFWNDS SRANVEWRPR
     CKIYNVLMMG LTETELKEEI ALQSIKINDK CNSVSDFMES YDSAAFEVQS GPYSMHMDAA
     LAAEFRSSKE SKNDWNRRTV SKSKGNTNHI DTITWMKPKS TNAVLQPAFK EKVFAQLSSS
     PNSNLPRTEF EYKNQMTATN SLALNTLKRL SHANSGVTQK IISKLFPDLA IKKSQSSLRQ
     KANIQPTDLT GSSSSLSDTG SQYKRSPNPK LLHKQKQLFD DNKKEASCGT SILSSQSSGN
     QRVQDKNFLL SETSLKTSKP NNKPKNGIKG DSWIEIENPS VPVDAELASY LIPNRWKDVF
     PKYVAKKYTK WRSFTTPAEL PLTTSMFPTP FDFEHQFSLR NHTVSLNIEQ EGYQQSVFDL
     LQNMIYVRLL AGFQFCLGKN VTRVEKARDK DTDGSRITHL INKENYRDVS IYLRIDNEIH
     RIVCFDETID VQKYIKHDDS KLLQSFAKYT PYVKTRYEVE YRELDLDPVK TRRESYNWNQ
     IDQVLAGFND TIMDPATQKR FRCKFVILPA EIPPNTFQST INGRKETLTA EEIRLEGLRK
     IISSISRSRL RTEHEKKDKR SHKEEILPEV LFYTGYLFDF IEEHNDFLKN SGAAVKNSIF
     MEDAETLSKD ADLTKIAYEL QHGVYQIKLV NRKWHWKRHE NCFIGLELVN WLIEHFSDVH
     TREDAVVYGQ ELMNKGLFHH VESRHGFLDG HYFYQLNPEF TTENKTLYKT STKHSNESHL
     MRKISTSNKS ESAKSIDPTI SVESNQQSED QITKPEEHSI TVLLSNAVTV DLDPSRKSYK
     LETCIAHYDR VHNPDHCFHI RLEWLTATPK LIDDLISNWS RLAERYGLKL VEIPWDELCN
     IPKINPFHSF MNIKLAINPW QDLEFKDETI FREQKFFYHI YLLEKSGFLL DNRASKFFQS
     EKTNSYQIIY SWGKPMFKYA QYIHYTGSCM AEIRESGDFF LAPNNLHISR MNTGNIGSKA
     SSHLKFTSDA QKIMLNFRKT CENYESLRDI FLEAKEKHID NRVDLDEYTS FQSFNLYT