ID   IML1_MAGO7              Reviewed;        1874 AA.
AC   A4R596; G4NIP7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; ORFNames=MGG_04160;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; CM001236; EHA47303.1; -; Genomic_DNA.
DR   RefSeq; XP_003719670.1; XM_003719622.1.
DR   AlphaFoldDB; A4R596; -.
DR   STRING; 318829.MGG_04160T0; -.
DR   PRIDE; A4R596; -.
DR   GeneID; 2677315; -.
DR   KEGG; mgr:MGG_04160; -.
DR   VEuPathDB; FungiDB:MGG_04160; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_0_0_1; -.
DR   InParanoid; A4R596; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000009058; Chromosome 6.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1874
FT                   /note="Vacuolar membrane-associated protein IML1"
FT                   /id="PRO_0000301774"
FT   DOMAIN          1304..1383
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1363..1386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1671..1749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1671..1688
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1716..1730
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1874 AA;  209930 MW;  F97316BC89E20BE6 CRC64;
     MHRNARGNVP GPSSLRQSIG TTKADRDRDR VPSVDAGAPR TPDTTTSSST TRHMHHQPHP
     RNGRQERKCT VTVNESFSRD EVLLNLDLFD NGIKPGSLMA IEVPPEKSGH ASLRKMPTQD
     HLDRDDSSMD ASQTGSTTTT DRRYLFIVKD MSKDMKLRHP KVELYVAKHV AEAFGMKKGG
     HVYLIPEDAN NPSIEASHVE LSFRDQYLSR ADMWRMAVGE LSERTVYQGQ VIYFLGTCKA
     QISAVFVDGR KVRSAFFGRH TRPIYRSESA RYILFIQMSR EMWDFDSDGS GEIMFNKVVN
     GFLPALFKKW MALKLKHLVS IVLFARVEYD TGISTEFAET ALHDSYFTGT QKSGSKRPYK
     DFYRVVVSEK TSVEWTSILY HLKREFGIFR RDISLHHQQA LNPMQSVSEE GATKQPYHRQ
     IRAESSLATH GNFLEAINLA STVYAHDYID RDLMRTGISV VVISPGAGVF EVDYEELRRT
     TEALVGNGIG IDLICVPKIP LHSVPLFRYK KVPEKGRRHS EKIKTHFHDG STPKYHTPAI
     GSYTSALGSS LSPTKNMSVP PRVESSLMSH ASNDEWSYAL PQWLHVSYWT GNSDEALSYQ
     GIALSASDNT CQDSQDEFAI RCRMYDLQMR SVLETNEIET TPLHADPSFP RKLIQPLPLA
     KFRRFDVDGI TLIPNLRHTG GLVDHVSGFQ KFAPDKHAKP GEKTIWRHLQ EYDDTKAHLP
     ASRRHLGFRP QNNADNVRMH GVESGSYLGA SMISERRVSI NHHQSPHPSV SSKTSSGKTP
     KFMRQISLGQ RGFGIAAPKV AVAEVQVENV AAATSMAAVS GSRSPLPVRM TPIKSNPQTS
     QSPQALTAIR DSPIAERAQE SGRSSRLAPS RPIHIRNNVQ SSDSTLFGTV GTMISSSVIR
     HAGAAPDAPE IKYSNALRAE DAQKVGISKL RAGEMPDQQA ILSPSAAVSP WLTVLNPCNP
     EANKVDETNL YSRWQHVFPQ PSEMKVMKWK SLCTPAAVPL TTEHFPTQAQ FDSEYQRQPY
     NVSQEFDDEL TEEPKTREEL LKELISLRFS QGFQVVVGQA VAKAFGQKQM KIADILSRDH
     SAEDGTSIFL SVGNTIHQLS CVNGTEVEVN IFTRKPALQA SNLEQPEVYK PAIRTIMDED
     YVARQIDIAT PKPERNWNYI DSYVAGHDLE LSESFRFWRA RFVLIPIVNR TSLDPAAGEK
     EEETRIEGTR RLGKLWQKHR YIPPSDRRFQ DLGPRHRKDP NPLDIVYKTD DPSVVIAAEL
     ETLPLLEGLE AGHRRAQLVT NKHQFRKSSL NLAQLAEAIQ QPVENGGVRM QNRRWHLRLH
     YNCFIGSDMI DWMLDNFEDL DSREEAEALG NVLMISDEDK LKDKEKDKDK EKDKDKEKEG
     STRRESGIFV HVEKRHRFKD GQYFYQISSD FAKPQPSTWF NQRWREASVP STPISEQPPR
     ESIRNSISHT LSEEESLTSG ATTPTAPILP YGGNKPRVML SKVMKYDVDH RKRSYRPERI
     DLHYDRLHNP DNCYHLRIDW MNVTAKLIED AVEGWAREAS LYGMRLVEVP IAEACTISDV
     NPFRKPFPIK LAVPPPDRQP VTFYDPTSFS PLAQPARLFY QKAILRKFDF VLDMESASSF
     PSNVDVTYSW GKPEFKYTQY IHRSGILLAE ITDEGDFLIL ANRLYSNRAQ AARDKEMRKE
     EEQQQHKHRQ GGAGAGGNGG LPGHSHVADL TPLSSPLFRA VNTTGSPKTA GQGAAGAGSH
     GNNIAPGGEH NVHSALIKFS LDEPNSIRLE MEKFCHDPVA LEAFYSELLD RAPGPQPASS
     IMAPTIISQT GSGTGPVADH NIPSFPSGGL PQGLLSSSVA GDGLSVIPSP VQQRVQSPAV
     LAASQLLRRG SVQY