ID   IML1_NEOFI              Reviewed;        1842 AA.
AC   A1DFV9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=NFIA_082130;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; DS027696; EAW18266.1; -; Genomic_DNA.
DR   RefSeq; XP_001260163.1; XM_001260162.1.
DR   AlphaFoldDB; A1DFV9; -.
DR   STRING; 36630.CADNFIAP00006591; -.
DR   EnsemblFungi; EAW18266; EAW18266; NFIA_082130.
DR   GeneID; 4586720; -.
DR   KEGG; nfi:NFIA_082130; -.
DR   VEuPathDB; FungiDB:NFIA_082130; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   OMA; RMYDLQM; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1842
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301775"
FT   DOMAIN          1338..1413
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          728..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1422..1475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1822..1842
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..770
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        771..800
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        928..943
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        956..976
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1429..1458
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1842 AA;  207096 MW;  0137105055DDA37E CRC64;
     MALRGPMKRS HLRQVSAPSV DSLSVPQSQS PEALYNDEHS HQDVHATPDE RTIRLSSASL
     ERRQCSLWVH DETFSREEIL FNQAAFSDLR VNVGDVIEIL PVRSPGDSIH SLKSDLGARS
     LRDSYLESGS AHLPDPMSKF KTPLQSRCLF VVKPLPQEIK ARHPKLEISV THSVANIFGF
     KNRTLVNISV VDRGQCSASH VDIAFRDQFL VRSDMWRLVM SELADKIIYK GQKIVFMGSI
     KATVKNIFIR GKKVLSGYFS PHTIPVFRSE SAKYVLFIQM SREMWDFDSE GTGDILFSRV
     INGFLPELFK RWANSDAKHL VTIVLFTRVE YGSSALGDPL PLSSESLRCI SSPNHVPTRD
     FYRVVVNDMA SGHWTTILDE LKKDFRTFLR DVSILKMDSP DTPTVDGVKV APKNKPAIIA
     GRPSTALRGN ILEAIHLASA HLAYDHIDRD MVHTGTSIIV ITPGSGVFEV SYESLSSTSE
     ALADRGIAID LVCLSPMPLH SVPLFKYKAP VERSGSSSFG DFHSSGYSPE MRQSFSFASR
     TPHLSPKSTM QGSFPGMTHK EHLSARSNEW NYGIPHWLDI SYWNPETYRE ARRIAKKDPN
     APIPFTVTKQ SKLFVPRVRM YEIQMMGVME SEQSDISIPY LLEGQGVSRT SNAGLGLSPS
     GLSSSRASFR RNSSYKAQLS DSLRPEPFLQ SITNPKDVML AKSKKTPNQV IAWMDQYDEA
     VFQPFAKRRQ QRKASRPKRP SEPEVQVSNA HERLSARSVL RLREHETNSN SGDRSYPTRT
     IPRVSETSLS APQGPVPSKT SSPKKPALKA PSAARTPRMS RTISFALLGF GATPPRAQAS
     TEVNVEHARA QPTSGQKKPS VGFMDTRSVE SFSGSDSASI STVIDTSLRP ASPHPAPQKS
     AMTPTRPISI KVPPRQPSED TEPVDRTVLP ESYSTTSTAI PFTGDGRRDS RTKNGPRFEL
     TVSGGSRESS IKSPQNKALA PWVRSINPCN TSRDVLRDTS WFGRWQHAYP RPPHVAVVKW
     KSLKSPAILP LTTEEFPTAQ ELGSDYLQTP YRVFPNDDPE GVEVPKTRGI LLREMISLRL
     SHGFQIVIGK HVAEASGQPA LETLNVFDTR SLERDGATVF LSKGNTIHRL ICVDGGEIEV
     TRFTHRTSST LAAGKRDDFS LYTPAMRTIL STEYELKNIK LDPTAEDYNW NYADNYVAGH
     RDYLFNPAQQ LQFWRVRYVL IPMPLQVNNR RHLQSFNEDN EEEIHLLGIN QLTHIWQRHR
     YVPPEEKRFE SSNEKKDQNP LNIMYQTRNP SEVVAAELDR ILLSDPGLDN SPAQLLPESE
     LLERSSISLS SLAQIIQGEK GVRMMDRRWH WRLHYNCFIG FEFTTWLLQN FRDIDSREEA
     VQFGNELMKH GLFQHVEKRH NFRDGNYFYQ ISSEYRVARP ESRGSWFPQK KSDKTVPSTA
     ASENPRDSPV NGHSRSDSVE TLPPHMPATP SKSKNKATIM LSKMMKYDVD PRKRSNRPEV
     IDLHYDRLHN PDNCFHIELS WMNTTPKLIE DTVLSWAATA EKFGLKLVQV PIAEGCAISR
     TQPFRKPYRV SLTVPPPPGP VPTVFNTATF SQLGSSDRHY YHKAMLRKFD FVLDFEARSA
     FPADVEVSYS WGTPDYQYPQ YIHRSGSLLV QITDEGDFLF LANRLVSTRL AAATREGSRY
     ERMDRPEHLR ARASTYDPLD RISPRLSPLV RPLHDIGSPI SPQGQPSIDS AHLYRAPEHI
     LKSFEEFCND AARLEQFYSV SHARPVSTKV GPAPTTLMDS SIPTLELPAS VVSHHIHPPA
     LMSRASVDGS IPSIDAMTRA RNDSLSYKGS PKSGSLRPLN MT