ID   IML1_NEUCR              Reviewed;        2004 AA.
AC   Q7S9J6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=NCU07710;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002239; EAA33060.3; -; Genomic_DNA.
DR   RefSeq; XP_962296.3; XM_957203.3.
DR   AlphaFoldDB; Q7S9J6; -.
DR   STRING; 5141.EFNCRP00000008014; -.
DR   EnsemblFungi; EAA33060; EAA33060; NCU07710.
DR   GeneID; 3878444; -.
DR   KEGG; ncr:NCU07710; -.
DR   VEuPathDB; FungiDB:NCU07710; -.
DR   HOGENOM; CLU_000935_0_0_1; -.
DR   InParanoid; Q7S9J6; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR   GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..2004
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301776"
FT   DOMAIN          1330..1422
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1042..1061
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1374..1401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1441..1482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1684..1732
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1754..1775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1977..2004
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..128
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1441..1480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1761..1775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2004 AA;  222206 MW;  1B75C7340E640E42 CRC64;
     MASRNFSSGV PGHVRPPNWS SHLRQFSRNS LERIPDMPRS PDTVSSNSTI RDRPSSSSRR
     SRFERRWTVT VNESFARDEV LLNLDLIGDE ATPGSLMAID VFRPDAEKQA QGSHHHHHHH
     HHHHHKQPPP DRTKEAAESQ QRYIFVVKDM PKELKARYPS VEVYVAKHIA DVFGMRKGSQ
     VTLTPIDHHN PAIEASHVEL CFRDQYMSRS DMWQLAVREL SEKTVYKGQM VLFMGTLKAQ
     VTAVYVEGRK VPSAFFGHNT KPIFRSESAR YVLFIQMARE MWDFDSDGSG EIMFNKVVNG
     FLPALFKKWA SLKVRHLVSI VLFARVEYDT GISTELGNPD VQNDYYTGVQ SSGDRRPYKD
     FYRVVVSEMG SGEWTKILYQ LKREFNYFRR DISTFHQKAM HSFSSSDDPA DQQAALNRIT
     AEASRAIYGN FLEAINMATS LFAHDYIDRD LMRTGISVVV ISPSPGIFEV EYDALRRTTE
     ALVGNGIGID LICIPKAPLH SVPLFRYRNP EYSTEPTHHH KAKTAPSLSS TPKQTAPTIG
     SFNSMAGSYS PSRGTDITLH GDYAGSGLAQ DEWNYALPQW LHVSYWTGES EEALSYHGIA
     LSVSDVSKTR SGDDFLIRCR MYDLQMRSVM ETNEIETKPL HLDPYFPHKA LQANNVPKPF
     IDQDGNVFIQ NLRIPETLFD HVYGFQKFAP DKHAKLGEKS LWKQLQDYDD SRARQPSFRH
     TLAPPSHIRE YDDSVRRHHA DDASLLGTSY TERRPSTSAS QMTMTGHRSS QRFNADKPES
     RNRKTVDFDK LNSKRSPTIT PKVPKFMKQI SLGSSGFRIA APKAATAELS IESVNADRSL
     ASSRALMNAG TVATPAKAAI NRSMSPQMFA SGTPVFSPWG ATPGSFAPSH QYFEGTPSRP
     MPIKSQQIPT DPAANMLSGS MLASTLRADY VPDNRDLFYS DAIRAEDAKK VYNNKLLAGA
     VPELPSTLSP TTALSPWLTL VNPSNPDSNK VDIATLYSRW QHVFPRPNET RVMKWKSLCS
     PAAVPLTTEY FPTKAQFESE YHRQPYNVSQ NADDELAEEP KSRDEMLREM ISLRFCQGFQ
     VVVGPAVAKA FGQKQLKVTD IFSRDHTAED GTSIFMSVGN TIHQLSCVNG TEIEVNIFVR
     KPIASAGLYN DRYLYKPAIR TLLDHGYKTR SYDMVAPTPD RNWNYVDAFV AGHNDELSEH
     LRFWRARFVL IPMTARHSFF PKTQYGDSEE EIRIEGIRKL AQMWQKHRYI PASERSFQAS
     RRKKDMNPLD IVYKTEDPSV VIAAELETLP LLEGLEGGHR KGQLVTSREQ FSKKNFSLAA
     LAEAIQQPVE NGGIRMQNRR WHLRLHYNCF IGSDMTTWLL ENFEDLEDRE EAEELGNRLM
     VTSDDKSKDE SKDGRKDGGG LFVHVERRHP FRDGQYFYQI SSDYAKPNPP GWFNTRRVPV
     SVPSTPHSEV RDSPRSNVSM SRPTSIHEDS SPTSGTVTPT AAMMAGGKKP RVVLSKVMKY
     DVDHRKRSYR PEVVDLHYDR LHNPDNCYHI RIDWMNVTAK LIEDAIEAWA REAALYGLRL
     VEVPINEACD ITEINPFRRP YMIKLAVQPP NQQPITYFDP NSFTPQAQPG RHFYQRALLR
     KFDFVLDMEP ASSFPYTVDV SYSWGKPDFK YTQFIHRSGT LIAEITDEGD ILILANRLYS
     NRTAAQREKE MQQKGGGSGA GGDNLGLGPG PGRISTPGLY GPNAHPDQPN AVSSPLVKPT
     TAFLSPALRP HLIGPLASGP PSTNGFGTTG QPLNRSTVTV PVTPVIQDPE VIKDELESFC
     RDRSALEAFY RELLEREAHP PAPNTTPGLA PVKIPSTTAT KDSTLAFATP HLGAGQNTTS
     TGHTVPDTNI PSLGLPPGVL AAIGGTGLSN LSDLQLVGSG TGLGISPVRV GSPSLLSAAS
     AASAGHPSHS TMMRRASVQE GVMGSRIGLG FGGGASAAAA AAQAAAAAAA AGASGAGAAG
     SSSDAGGAGN IGGGAGGDAG ASEH