ID   IML1_PICST              Reviewed;        1489 AA.
AC   A3LRB2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Vacuolar membrane-associated protein IML1;
GN   Name=IML1; ORFNames=PICST_82645;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; CP000497; ABN65709.2; -; Genomic_DNA.
DR   RefSeq; XP_001383738.2; XM_001383701.1.
DR   AlphaFoldDB; A3LRB2; -.
DR   STRING; 4924.XP_001383738.2; -.
DR   EnsemblFungi; ABN65709; ABN65709; PICST_82645.
DR   GeneID; 4837902; -.
DR   KEGG; pic:PICST_82645; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   InParanoid; A3LRB2; -.
DR   OMA; REMWHFE; -.
DR   OrthoDB; 45642at2759; -.
DR   Proteomes; UP000002258; Chromosome 3.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..1489
FT                   /note="Vacuolar membrane-associated protein IML1"
FT                   /id="PRO_0000301777"
FT   DOMAIN          1082..1157
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1176..1209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        694..708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1183..1209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1489 AA;  172308 MW;  C3979018BF948B24 CRC64;
     MQHARIFNSG GQSRRNHSGS SNVLSSQSLS KSNSMNSMSA SQMSIQIGAS RVTSSSSGNH
     FMNRNMRSTI TVGKKHAPIE QQIHQTQTPN LTSTVQPNLK DPIPLTVWFH DLRTSDEDVI
     IDSNAIPGGV RNGQVYMLQS LETEDSKKLL FVINDRNIRD NNAAAQDDLQ SSKFQISLIS
     NPLQKLLDIP PRSLVQIKRI QNLAKVEADS VEIFIKDVNL SRDSMWNFSS TLVNSCVHID
     KRLLFLNNRT GIVKYIYKNG RNVFSGYIGE NTKVTFRSES AKLTVLVQLS REMWHFEENG
     EIMFHKLVNN LFPKMFKRWR DRNTHHAITI VLFTSMDLTD IPWTTLGQGE RPNNRRDYFR
     VVVDQVNIFH WDKIMANLRL EFANFKRDIM LNQQDTNHYT MDGEPLPSVK GNILEAVNLG
     MTLANNRFIN TDLKHSLNHY IVVTPGTGIY DVDYELMLET SKKMSTIDYG LDIICLSQPP
     LHVVPLFRFS KDGKVKHVVP NWCDISYYKD SNQSANSWIP RCKIYELQMM GVMENNMNQI
     RIDRFQVTQK APTMIEAMDN YDNDLFKPVN HRKYIKENDE KAIDSYEIKE KNNSKFKPTT
     LKNANATLSL IFNNRTRLQP TELTPSNSSV LGTVTHSNGE ALSTLYNLNK ISDDRTISSL
     APSISSTRSI SSKRSMDILR KETHSPRLIK SDSLFKTETG ASTPAEPRTT KSVERERKSR
     HLMKHYESEN PTDIFWTEIE NPSQEYRADT LLYPNVSRWS NAFPDKIRRR LVKWRSLQSP
     AALPITTSVF PSVKILETEY TFQIYNVLLN YENYLELETT HELMREMIQL RLLLGFQICF
     GDQVKKAESE RKPAGNVESL IKYLPRHSSL GARIYMSLGD EIHRIYLDYN GNLNVQLYHK
     TVTNEENKIT LGQAKLTNYF PLIRTRYADE YSTAKIDGIN SKPKMYNWNQ FDQYLAGYED
     AMPDANKDFY KMKFVVMPAP IPKNAFYITN ENLTDEEIRV EGLRKLIAMI EKGKYLKRKV
     TSKKEEILPE IVFYTGNLYD FLNEEAQNFD NTGNQAGLMI PESMRFNKSI KLSELAEELQ
     TRSTGLPLVD RTWHFKRHLH CFLGSELVSW LLECFEDIQT RDEATSYGQS LMNKGLFKHV
     ESRHGFLDGY YFYEFESEYI DKTYIESKKG WFGIKKTSSE KPDTDSNTPV YTRNNSDVES
     LSSPALPSQD PLDLKRITST LITDSGASSL EGSRRRKKFI LSRAVKYNVD SLGKSFRPEI
     VTVHYDRVHN PEHCYHIRLQ WLSTTGRFID EAITNWSRLC ERHGLKLVET PWKELCNIPS
     ISPFHSFVDI KLCVNPLVDP EFSDVKILRK NRFYYHLYFL KKFEFLLDNR SSLFFSKDSI
     EISYSWGKPS FQYAQYIHKN GTYIIELRDN GDFFLAPNNI HITRVNTTLT SIPDFDGSIT
     TYNTNSQQVM LNFRSACQNE DYLKELFREA KSNWREEFPL DMMPTDLPQ