ID   IML1_SCHPO              Reviewed;        1496 AA.
AC   O74788;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Vacuolar membrane-associated protein iml1;
GN   Name=iml1; ORFNames=SPBC26H8.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-738, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21096.1; -; Genomic_DNA.
DR   PIR; T40016; T40016.
DR   RefSeq; NP_596645.1; NM_001022567.2.
DR   AlphaFoldDB; O74788; -.
DR   BioGRID; 277086; 9.
DR   STRING; 4896.SPBC26H8.04c.1; -.
DR   iPTMnet; O74788; -.
DR   MaxQB; O74788; -.
DR   PaxDb; O74788; -.
DR   PRIDE; O74788; -.
DR   EnsemblFungi; SPBC26H8.04c.1; SPBC26H8.04c.1:pep; SPBC26H8.04c.
DR   GeneID; 2540559; -.
DR   KEGG; spo:SPBC26H8.04c; -.
DR   PomBase; SPBC26H8.04c; iml1.
DR   VEuPathDB; FungiDB:SPBC26H8.04c; -.
DR   eggNOG; KOG3572; Eukaryota.
DR   HOGENOM; CLU_000935_1_1_1; -.
DR   InParanoid; O74788; -.
DR   OMA; RMYDLQM; -.
DR   PhylomeDB; O74788; -.
DR   PRO; PR:O74788; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IDA:PomBase.
DR   GO; GO:1990130; C:GATOR1 complex; IPI:PomBase.
DR   GO; GO:0005774; C:vacuolar membrane; EXP:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; IMP:PomBase.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IMP:PomBase.
DR   GO; GO:0010508; P:positive regulation of autophagy; IMP:PomBase.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR045838; DEPDC5_CTD.
DR   InterPro; IPR027244; IML1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13179; PTHR13179; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF19418; DEPDC5_CTD; 1.
DR   Pfam; PF12257; IML1; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Vacuole.
FT   CHAIN           1..1496
FT                   /note="Vacuolar membrane-associated protein iml1"
FT                   /id="PRO_0000301778"
FT   DOMAIN          1116..1191
FT                   /note="DEP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT   MOD_RES         738
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   1496 AA;  169995 MW;  4750327975C1BFE4 CRC64;
     MAITLNLWTH ESSLFPNDAV LNYDLVPSAK PGDIFEIRAQ NGDEIALQHN HSSTGKLHAK
     REKEPVYLMP SPLTDDLKRR HPNLQLSVVS HISSLLNIKN REPVVVKICE DKTNLEAEHV
     VIFFRDQFIS RSDMWKLFRE LCGKCVYLKQ RVSFIGDVPG EIRCIWRKGK KCHSAYISER
     TKPIFRSESA RFLIFIQMSE EMWHFEEDGE LNYNKAIDGF LPDLFSFWRD LGTHHLVSII
     LFTRVEYSHH GPMCVWQPRS QKNSEKGSSI YPQNSFNASI DNEGGPYEDF FKVVVDNVSS
     RDWQPVLANL KLELAKFRQD VIVRKIKDEN GREIEYICGR MTGSQEGNFL EVINMAVFQF
     QSDYIDRDLS RTGTSIIIVT PGTGLYEVNE KMLHLTSKSL LNTVVGMDIV SLGKVPLFLT
     PIVRYKNPVK NKKRSQLTSR ISSSVSPSNV IPNSLTSSVS NFSVSSFLNN LKEDTEWLYT
     FPIGCNISFY STTEMRSLRS PWENLMREHQ FEPTAKMHEL QMMGVLEAES AKISIPLLQS
     DPLLKGSVFS EEVQEDYDER QFTGEAAVSA NDVLSSSSPR HFSSHTPVNV DKSSYLEMNG
     HSLSTVISGK ESISSFGAKV DDLKSTSKES ARQFGKSALT ERLQKLAGNS SNVSSSLQTS
     SSNKSSLLTK KSSFPALLKG FLALPATVTT SANPLGFKST IQRPIPIKNN EDSDSCKAFS
     QAPPIATKKP PTFLKPNSPE YAKTVIPKSS TNLENEYQTP WKIIQNPFKL KETTADNDPV
     SLRWEHLYMK VQDVRKFNWL SMCTPGALPL TFSYFPSEEE LNDKFEEYTY TIGIDPEFTQ
     MNQQELLAEM ICQRLSRGYQ IVVNPAAAVS YSGNPKANKA GTITDFSRSV NNQRNGHLTV
     GSDAVCLSLG DSQFHRLSCD SVGYNIEVKR YVKKVSGQGK MRYDYNFWSK NECKYVKSNI
     TFSANDSANY NWNYVDQLIC GFETYLPDSV KYWRARFVLL PMSTTSTHVF QKYQLLDHAD
     ALSDEEFRVE GIYKLSELLY KGKIDPMNDS NNKTPNTSPA ELLGIKFTTL PMAQYIHSEL
     EALRLDSSRN EQSLFMPNKR LDCSADLHTI AKEIQGPGGP KIDDITWHYR IYENCFLGSE
     FVSWLANTFI GINTREEALK YGNKLLSLGL FDHALKKHPL LDGYYVYRIS PDYSIKPVSN
     RPYRSWFSRK KDSGQKHLDN KIITESEAGP SRLELSRRIL FNADVEKKNG KSETVTVHYD
     LLHNPASCYH IRIEWLLATA SVIEKLLQSW SRILERYGLK LVEAPIHEIA AVGELNPFDQ
     VSIISLALDP PPIPERAPLV NDPVNYSKNW WNVKILEHFD FILDTEAAST FPKSITAVYS
     WGKPNFRYVQ YIHRTGTVLV QIDDDQRFLW LPNRLHNSKV SKLSFTKSNK STLNPNLKET
     AEELERKFRE FCSNKDELDQ FYGIVNHASD DRRSIYSSAS THASNASADD ASNVNV