IML1_YARLI
ID IML1_YARLI Reviewed; 1547 AA.
AC Q6CAP3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Vacuolar membrane-associated protein IML1;
GN Name=IML1; OrderedLocusNames=YALI0D01067g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IML1 family. {ECO:0000305}.
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DR EMBL; CR382130; CAG80455.1; -; Genomic_DNA.
DR RefSeq; XP_502269.1; XM_502269.1.
DR AlphaFoldDB; Q6CAP3; -.
DR STRING; 4952.CAG80455; -.
DR PRIDE; Q6CAP3; -.
DR EnsemblFungi; CAG80455; CAG80455; YALI0_D01067g.
DR GeneID; 2910415; -.
DR KEGG; yli:YALI0D01067g; -.
DR VEuPathDB; FungiDB:YALI0_D01067g; -.
DR HOGENOM; CLU_000935_1_1_1; -.
DR InParanoid; Q6CAP3; -.
DR OMA; REMWHFE; -.
DR Proteomes; UP000001300; Chromosome D.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Vacuole.
FT CHAIN 1..1547
FT /note="Vacuolar membrane-associated protein IML1"
FT /id="PRO_0000301780"
FT DOMAIN 1018..1093
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 489..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1393..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1547 AA; 174836 MW; B32EC42DCA588889 CRC64;
MASCATVCLP TCGTRLSGHS RSRSVWKLVS YITLLHFILK VFLVFLTSFH LLTQLSIKSG
NLLSSLGVAA RSQVQIKLRK KEQVEADLVE ICFKETYLTR ADMWQITTML RESCVYHQKR
IVFCDVIRCW VDSIFKNGRK VFSAYIGPNT NIVFRSESSR MIIIIQLSQE TWHFEETGEI
IFHRMVNSLL PDIFKQWEEN EHHHTVTIVL FTSVSMDSHA VKLKRGEKAK DVQDFYRVVC
DQVQLSQWEQ IMVRLRFEFQ NFAKEVLTES HAKSHTEIRG RILPSVKSNI LGAITLAASL
VHSPAIDRDL RRTNVEVIVV SPGSGVYEVE YDALYRASEK ISSTEVGVDI ICMSKAPLHV
TPLFLYKPKK CSNQLEYCVP SWIDISYYGD SDFFTNQWVP RCKIYEIQMM GVMENELSAI
TIDYLNKPSG KKPLSEYCRE YDASLFGPIA VELSVEDAAS VVSKMRSDTF PKLPVKQLLS
SKGSISSLHA PTAVTSKTPP PKASVKVADV RPSPAASKPR VSALTSLLAF GVRAEKSAPA
SPALSAVNTL SSIQSMDLRR DNDSVKRDTE SIVTDDTVHN TKAEPRITEI APIAPSLPFA
PNLKPKKSTS TLSQSPTYNR IAATPDQEVE RRSSLSQKVQ MGLSGSPLDH RGKVAKAASA
NAKSINTETT PEKRNMMWRN IRTPSNISQD EMLDILTYSR WRTVYPQKTK RRSAKWKLLA
SPAALPLRTN IFPTVAELQT EYRFQVYDVS LDTDMENVLG IHGLFREMVS VRLCKGFQLA
IGSRVRHVES QRSDGRPSAI TTDIGKDALG AVVYLTTGDQ VHRISCDYSG MMNVQIYHAI
DKVDIEEPVF DIYARRTYSD KFKHFIFPPF DTSSKRLNWN LYDHSLAGYD TAGSAATQTR
LNQLRVVLIP SFLSRSKNLG HDDSSEVYNA EEVRLDGLRR ILGGIYRHSI SRDEDKERAK
IAPNLKFYTG ELEDFLFQIV ESNPAELAGG RDSLFMKRNQ RFDKNIKLAQ LATELQAPKG
GIRFFDRRWH WKSYPHCFIG QDFVEWLIDN YSDIDTPDEA VAYGNELMKK DFFVHVEDRH
AFLDGHYFYQ LKSEYATEAT DSKPAEEKSG WFNSKRSMAS VSSEKSLGRF KGSRNQSVQS
FGDFLSLSRV TSRSSNDQKE EEINPITVEI SKSVRVDLDP SKKSYRPETV LIHHDRIHNP
RKCFHLRFEW ANTTPKFIED YISGLTRTCE RYGLKLVELP ILEVSALLEH NPFASEITLD
MPTLDQLSGL PPHVLEYYAS DPHAIAREIL HHFGFVIDTL SMSDWKLAEV QIRNSWGVPT
YKYSQWVEKN GLLIAQVVGD QIIMIPNNLQ LNRQSGAQSN AIQLQSEAQG IILEMQYLMC
RSEKVRDMLG KVNLSPEASP GTMTPGEEGS KNGTPKLAIE AKMEGRVESP QVEWREDVEI
APEVEHKGGA DGDENDEEGD EKSEEGDKGE SENENAGMGM EQDGENENEN ENENENSKDN
KANETTSEVK EVPAGVEIEH KEHVEEDKSD GPEPKKEDKG KEVEDDK
