ID   IML2_ASPCL              Reviewed;         721 AA.
AC   A1CQ80;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=ACLA_025180;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; DS027059; EAW07801.1; -; Genomic_DNA.
DR   RefSeq; XP_001269227.1; XM_001269226.1.
DR   AlphaFoldDB; A1CQ80; -.
DR   STRING; 5057.CADACLAP00002349; -.
DR   EnsemblFungi; EAW07801; EAW07801; ACLA_025180.
DR   GeneID; 4701463; -.
DR   KEGG; act:ACLA_025180; -.
DR   VEuPathDB; FungiDB:ACLA_025180; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..721
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333339"
FT   REGION          177..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  80747 MW;  F584954572C841EC CRC64;
     MFRVGSWLYG KKPANASTQS LDSLVELRDP ATLILNDDVD GAEDGLAEGT SSFHNLGRGV
     VAFIRATLGF EQDIMRQASE RLNEAETTAS VDQHRAQHNS QAPNTYHSAM YTPGTEFALC
     QAMAQLMGAV VGVLNESLTE SIKGFYRLRK AYITLDAILK MEQKYLQESR MATPIESAAP
     GSIPLSMKRQ GSSNLQSSSS SISSAKIKKA ASSATTLAAP VENTDLSERL TGLNLSSETL
     APGDVKEAST LGPADMLNHD PDSDIFHNQI DIFVHSGSNF CFGILLLLIS MVPPAFSKLL
     SIIGFHGDKE RGLRMLWQAS KFHNLIGAIA AFSVLGYYNG FVRYCDIMPD SIPGQDEDVQ
     GYPQERLELL LAKMRKQFPK SQLWVLEESR MCGANKNLDR ALELLCGGES SPLKQVEALR
     LFERSLNAMY LHKYELCAAS FLECFELNTW SRSLYYYITG SCHLSLYRNA LDKDPAKAAE
     HAELAEKYFR LAPPLAGKKR FMARQLPFDV FVARKVAKWE ARAKDWKVPL VDAVGVDPIE
     EMIFFWNGHS RMTDEHLLES LQKLAWCESS ANKTWSREGP EEKAILKLLR AAVFRSLRKH
     SQAKDLLEDI LSQDRNLFKG HLKDDWICPV AHFEMAANMW MERPTYIAIH GGSKEFTDPE
     ATEPADSSKS LEYEREKVHK CKEYLEKAAK WESYELDARI GLKVTAAMEA VQKWENTHPP
     A