ID   IML2_ASPFC              Reviewed;         725 AA.
AC   B0XQF6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=AFUB_009780;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS499594; EDP56270.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0XQF6; -.
DR   EnsemblFungi; EDP56270; EDP56270; AFUB_009780.
DR   VEuPathDB; FungiDB:AFUB_009780; -.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   PhylomeDB; B0XQF6; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..725
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333341"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  81199 MW;  6E192EF875FF3DAA CRC64;
     MFRVGSWLYG KKPAANASTQ SLDSLVELRD LEDAMRAATL ILNDDVDGAE AGLAEGTSAF
     HNLGRGVVAF IRATLGFEQD IMRQASERLN EAETSASVDQ HRAQHNSYAP NTYHSPMYLP
     GTEFALCQAI AQLMSAIVGV LNESLTESIK AFYRLRKAYI TLDAILKMEQ KYMEESRAAT
     LVESTTSGSV PSSLRHSSSN LHSSSSSISS AKGKEAAADT LAAPSNDTDV QERLADLSLS
     GEPAVAEDPG QTPTPINTDI LDHDPDSDIF QNQIDVFVHS GSNFCFGVLL LLISMVPPSF
     SKLLSIIGFH GDKERGLKML WQASKFHNLI GGIAAFAILG YYNGFVRYCD IMPDSIPGKD
     GDVQGYPQKR LELLLAKMRE RFPKSQLWLL EESRMSGANK NLDRALELLC GEERSPLKQV
     EALRVFERSL NAMYLHKYEL CADSFLECVD LNSWSRSLYY YIAGSCHLSL YRDVKETDSA
     KAAKHAELAE KYFRMAPTVA GKKRFMARQL PFDVFVARKF AKWEARAKEW KVSLVDAVGV
     DPIEEMIFFW NGHSRMTDEQ LQESLQKLAW SESSANTTWS REGPEEKAIL KLLRAAVHRS
     LRKHTQAKEM LEDILGQDRT LFKGHLKDDW ICPVAHFEMA ANLWMERPTY IATHGGAKQD
     SNKESARPAS VNDALQYERE KVRKCKEYLE KAAKWESYEL DARIGLKVTA AMEAVQKWES
     THPTL