ID   IML2_ASPFU              Reviewed;         725 AA.
AC   Q4WT68;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=AFUA_1G10360;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; AAHF01000004; EAL90364.2; -; Genomic_DNA.
DR   RefSeq; XP_752402.2; XM_747309.2.
DR   AlphaFoldDB; Q4WT68; -.
DR   STRING; 746128.CADAFUBP00000960; -.
DR   EnsemblFungi; EAL90364; EAL90364; AFUA_1G10360.
DR   GeneID; 3510657; -.
DR   KEGG; afm:AFUA_1G10360; -.
DR   VEuPathDB; FungiDB:Afu1g10360; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   InParanoid; Q4WT68; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..725
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333340"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  81198 MW;  FB7B58DA9C891AC7 CRC64;
     MFRVGSWLYG KKPAANASTQ SLDSLVELRD LEDAMRAATL ILNDDVDGAE AGLAEGTSAF
     HNLGRGVVAF IRATLGFEQD IMRQASERLN EAETSASVDQ HRAQHNSYAP NTYHSPMYLP
     GTEFALCQAI AQLMSAIVGV LNESLTESIK AFYRLRKAYI TLDAILKMEQ KYMEESRAAT
     LVESTTSGSV PSSLRHSSSN LHSSSSSISS AKGKEAAADT LAAPSNDTDV QERLADLNLS
     GEPAVAEDPG QTPTPINTDI LDHDPDSDIF QNQIDVFVHS GSNFCFGVLL LLISMVPPSF
     SKLLSIIGFH GDKERGLKML WQASKFHNLI GGIAAFAILG YYNGFVRYCD IMPDSIPGKD
     GDVQGYPQKR LELLLAKMRE RFPKSQLWLL EESRMSGANK NLDRALELLC GEERSPLKQV
     EALRVFERSL NAMYLHKYEL CADSFLECVD LNSWSRSLYY YIAGSCHLSL YRDAKETDSA
     KAAKHAELAE KYFRMAPTVA GKKRFMARQL PFDVFVARKF AKWEARAKEW KVSLVDAVGV
     DPIEEMIFFW NGHSRMTDEQ LQESLQKLAW SESSANTTWS REGPEEKAIL KLLRAAVHRS
     LRKHTQAKEM LEDILGQDRT LFKGHLKDDW ICPVAHFEMA ANLWMERPTY IATHGGAKQD
     SNKESARPAS VNDALQYERE KVRKCKEYLE KAAKWESYEL DARIGLKVTA AMEAVQKWES
     THPTL