ID   IML2_ASPNC              Reviewed;         692 AA.
AC   A2QQE8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=An08g02280;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; AM270163; CAK45273.1; -; Genomic_DNA.
DR   RefSeq; XP_001392344.1; XM_001392307.1.
DR   AlphaFoldDB; A2QQE8; -.
DR   PaxDb; A2QQE8; -.
DR   EnsemblFungi; CAK45273; CAK45273; An08g02280.
DR   GeneID; 4982541; -.
DR   KEGG; ang:ANI_1_1750074; -.
DR   VEuPathDB; FungiDB:An08g02280; -.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   Proteomes; UP000006706; Chromosome 8R.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..692
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333342"
FT   REGION          87..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  77268 MW;  E5C80F0AA83ADDB6 CRC64;
     MFRVGSWLYG KKPASTQSLD SLSELRDLED AMRAATLILN DDVDGAEDGL SEGTSSFHNL
     GRGVVAFIRA TLGFEQEIMR QASERLNAAE TSAANDQHRA QHNSHAPNTY HSQIYAPGTE
     FALCQAMAQL MSAVVGVLNE SLTESIKGFY RLRKAYITLD AILKMEQKFI MQARNSGNST
     STESLPRGAG QGAGSKSVPA SPVEPIDLKK ELSDLSISAD SEASASGPSD MLSHDPDSDI
     FKNQIDVFVH SGANFCFGIL LLLISMVPPA FSKLLGIIGF HGDKERGLRM LWQASKFHNL
     IGALAAFSIL GYSNGFVRYC DIMPDPVPGD DVQGYPQERL EALLALMRKR FPKSQLWLLE
     ESRMNGANKK LDVALELLCG EDRSPLKQVE ALRVFERSLN AMYLHRYELC AESFLECVEL
     NSWSRSLYYY IAGSAHLSLY RNIAGTDATA AAKHAEKAVE YFRKAPPLAG KKKFMARQLP
     FDVFVSRKIA KWEARAKEWK VPLVDAVGVD PIEEMIFFWN GHSRMTQEQL EESMTKLAWS
     ESEANKTWSR EGPEEKAILQ LLRAAVLRAM RRHDEAKEMI RTSIFSQDKS QFTGHLKDDW
     IYPVAHFEMA ANLWMERPTY SAIHGGPASS SEKPSTDSDM QLERRQVREC KEHLEKAAKW
     ESYELDARVG LKVTAALEAV EKWESAHATT SG