ID   IML2_CANAL              Reviewed;         866 AA.
AC   Q59ZW2; A0A1D8PFV5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; OrderedLocusNames=CAALFM_C114210CA; ORFNames=CaO19.7229;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW27021.1; -; Genomic_DNA.
DR   RefSeq; XP_715030.1; XM_709937.1.
DR   AlphaFoldDB; Q59ZW2; -.
DR   SMR; Q59ZW2; -.
DR   STRING; 237561.Q59ZW2; -.
DR   PRIDE; Q59ZW2; -.
DR   GeneID; 3643302; -.
DR   KEGG; cal:CAALFM_C114210CA; -.
DR   CGD; CAL0000188632; IML2.
DR   VEuPathDB; FungiDB:C1_14210C_A; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_0_0_1; -.
DR   InParanoid; Q59ZW2; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..866
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333344"
FT   REGION          292..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   866 AA;  97244 MW;  30EC29D62D8C5BAB CRC64;
     MLKGLRKKAS ILSLGSMASQ QSTSSAINSE SNYDKILTQV YDFEIALKAM DYLLDDRTKT
     GTDLLQNEAS KNNNSEQPHA IFPLALGVME FIEATLGFEP EVMAKAHKTL SEAENASLNN
     SKYNLKYQLA TSMIYPPGTE FQVTFAESTL LNALLMLLTE NNGMVESAKA LFKLRRAYQT
     LDAVYKKIKE SEPIFNKNLA KLKKEAAMQG NGTKSNSIIT TENFSISTVD LPGYSSQTSS
     TSSLPQDISL MKNLEKIYLM RKSRIEGATL ANNVNPERVN LFEDSNSSLT LAKQSNPKYE
     EQRVDNANNN NNSHDVGEDD SSSSDNEYCD ASEEFDIEDT LNLPPPQIHS SAQSVLSSIE
     TSPSSAQNAS DNHLHVSTID EYIHSGVQLC FGILQVVLSL IPPAIGKVLS IVGFRGDREV
     GLRLLWRTAI TCRNVHGELA LLFILVFYDG PVQFVDNGFR LPDQGNDKKI ISLDNKATVS
     EAELDIILER PELYTSQLLR RARRMFPHNA LWILQEGRML AAEGDLALAT KTMQDFTDDP
     ANEIQMQQAE ALLVFDRATI YIYQHEYDNA ARDLIYLIDI NSWSKAVYLF MAASCYLEKY
     RMIKMDIISV DNKESEMAKY SSLFDKYLDL ALSYVPGHGH NAVGKKGGIG GSNKQMPFDK
     FLLRKSRHIE ARKKKYPNLP TADIVGTSLI HELIYFWNGY NRMSSHDLEI ALKLLGYSGA
     PNSEYSANTN GNLYALIEET EDEAMIRYFL QGITLRQLGS INDGLGLLDN HVISKYVISE
     PLHQFRFHKM TYSPYIYPTA LYEKTMFVWL LRTKNTAKLD VHQAVQESKS WLKRAEIVGE
     GDYELSNRTG MRIKAAGDRL EQLATL