ID   IML2_CANGA              Reviewed;         743 AA.
AC   Q6FJV9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; OrderedLocusNames=CAGL0M03179g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62461.1; -; Genomic_DNA.
DR   RefSeq; XP_449485.1; XM_449485.1.
DR   AlphaFoldDB; Q6FJV9; -.
DR   STRING; 5478.XP_449485.1; -.
DR   EnsemblFungi; CAG62461; CAG62461; CAGL0M03179g.
DR   GeneID; 2891493; -.
DR   KEGG; cgr:CAGL0M03179g; -.
DR   CGD; CAL0136953; CAGL0M03179g.
DR   VEuPathDB; FungiDB:CAGL0M03179g; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_0_0_1; -.
DR   InParanoid; Q6FJV9; -.
DR   OMA; FWNGHSR; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071218; P:cellular response to misfolded protein; IEA:EnsemblFungi.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..743
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333345"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  83498 MW;  9264820C0C2DD029 CRC64;
     MFKVFGALSG KGSSDSNGNS TRSSINEKRT KLILKEANDF EIALRAMDYV LDDRTEEGLA
     LLRENEKVNG QNQTITVLAR GVIEFLQATL SFEMEEIKNA SNTLAKAEQL SWKSRTEAQK
     SGIRNSSIYP PGTVYAVTYT ESCLLHALLM LFTESMMDAA KALLKLRKAY SMLHEIMEVV
     KKSELSRKVS SSSAVSIQSN GSFVSEEATF VSADIPYQLS ETESNDPELW AFAEKIYKMR
     KLRLSGAHIG NTPAISRLRS GLGLSASNKS EELANSEQSV LSDEAAERQA TIDEFIHSGV
     NLCYGILQVV LSLIPPAIGA VLSIVGFRGS REEGLRLIWK ATKDRNVHGC IGLLGLMFYY
     DGPFQFTDVD FDIPPALSNT KTSDSDTDRD GSISIDEMDG HALLHPGPIL EEALLHARAL
     FPNSALWLLN EARMLSSRGR LPEAIELLDS IDVESIHMRQ VKGLLVFDKA ITLVHMQEYE
     RAATNLLSLL KISDWSHAFY TYFAGCCYLE NWRMAQMGFI KDDKLEFYRE KAEELIFSAP
     KLLGKKTFKS KNLPLDRFML RKVEQFKATQ KKLGVKNILD AIGTSPIREI TYFYNGYNRM
     SKSDLEIAQK MLTSYHNPAI DQHDPDQELI KNLLLSLTMR RLGDVESGVK LLDEKVLPSI
     YYMQNGKVKY IKKTEDPWAY PTALYERALF TWKLDGVDNL SECRHWLVTA QNYAGDYELS
     TRVGMKIKAA LDRVEESLQH GTA