ID   IML2_CHAGB              Reviewed;         830 AA.
AC   Q2H2B2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; ORFNames=CHGG_04084;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CH408032; EAQ87465.1; -; Genomic_DNA.
DR   RefSeq; XP_001223298.1; XM_001223297.1.
DR   AlphaFoldDB; Q2H2B2; -.
DR   STRING; 38033.XP_001223298.1; -.
DR   EnsemblFungi; EAQ87465; EAQ87465; CHGG_04084.
DR   GeneID; 4391942; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   InParanoid; Q2H2B2; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..830
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333346"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  91454 MW;  8FA265B69455A145 CRC64;
     MSALRSWFRG PSAPASSKPS SKGTTPGPSP TDSTSTLAGK AKPAISPAEQ EARDMEDAIT
     AAGLIMNDDI DGAEALLRLR EDASTFHQLG LGVTSFMRSI LGFEKEIMTE AANRLNETEN
     RAWNDIKKAQ KEAEKAGNAS AGSTGYWYSK PAAVEPNAAG NGGRSKIYPP GSEFALVNAE
     AQLMNAVVGV MHESLTEAIK GFYKLRKAYV TLDGIMEAEA RYLTSIGQGE VKRAASTKAA
     SVKRASFSED PMPGTFDESE FSYLDDETQT PVVKESGNQS PVETAKGRAQ TAGEPIAVNQ
     DTTVLDEKLS RVAISKDSQP TDQPRPAPKE RPGDGTQTLG SFTLELLNTS GPDKALFNST
     VDVFVHSGAS MCFGILLLLL SMVPPAFSRL LYVIGFKGDR DRGLKLLWQA TKFPNINGAM
     AALVLLNYYN TFLGMADILP PEHGPDSPTS PGFTDNNSNK NEVETVGYPK EKCTALLATM
     RERYPDSRLW RLEEARVLAN SRRLDEAIAR LEANTDSKMR QITALNNFEL SMSSMYALDW
     PAMRDNFLRC VELNSWSHAL YYFIAGCAEI EMYRDAFHAA AALGDHDKEK GVLLTEAQKH
     KKAAEEYLRK APTVAGKKRF MARQLPFEVF VSRKLQKWEE RAKAVGVDLA DAVAVSPAVE
     MIYLWNGSKR MGTKYLEKAW TLLVWERCTA PAEKLAKIME EKDEVAIALL TESALLRQLG
     RGAEAKALVE PLLAMDRTVF KGPTRDDYCR AAADYEMAAV AWMEVWDLNS WPKGTAEEVQ
     AFQRQKVDEC REYLDKVSKS EGFVLDARFG MRVKAGMETV EWLRAKKGWA