ID   IML2_KLULA              Reviewed;         725 AA.
AC   Q6CSC1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; OrderedLocusNames=KLLA0D02244g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00264.1; -; Genomic_DNA.
DR   RefSeq; XP_453168.1; XM_453168.1.
DR   AlphaFoldDB; Q6CSC1; -.
DR   STRING; 28985.XP_453168.1; -.
DR   EnsemblFungi; CAH00264; CAH00264; KLLA0_D02244g.
DR   GeneID; 2893339; -.
DR   KEGG; kla:KLLA0_D02244g; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_0_0_1; -.
DR   InParanoid; Q6CSC1; -.
DR   OMA; FWNGHSR; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..725
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333349"
SQ   SEQUENCE   725 AA;  82016 MW;  AE6A7D4C8001FABE CRC64;
     MFRVFNALTG AGSPKATELS GEERTKFILQ QAHDFEIALQ AMDYVLDDNA EVGLKLLADN
     QATSPGDATV GALAKGVIEF LEATLGFEPE VMKKASTTLA EAEQLSLKSR AKLQKLNIKT
     SSLYPPGTEY AVTYTESCLL HALLMLFSES MVEGAKALFK LRKAYHMLQD ILKEINASEK
     RKRSSIYLQE INESTASFIS SGTCFTSYDI PYKLTPEEEQ DKELLDLANK VYSLRRKRLC
     GAHIGNSPAI NRLRDDVGAA SLKKGSDEET QEFQLLSDNA NINQATMDEF IHSGVNLCFG
     ILQVVLSLIP PAIGAVLSVV GFHGSREEGL RLVWKSTKDR NIHGGIGLLG LLFYYDGPFQ
     FTDIDFDIPA ARDDNLPVTE MDRPTLLHPG KILTSALLQA RALFPNSALW LLQEARMLSK
     QGRLKEAVDL LDSIDHNTIE MKQVKALIVF EKATTLVYMH EFERGAETML IMLSISEWSH
     ALYTYFAGCC YLEMFRKYEM GILNGENAAE KKAYYKERAT NLVFESANMV GKKKFMSKIL
     PLDRFLLRKV DQFKKFQNII KSSDPLDSIG VSPVHELIYF YNGYNRMTMK ELNLSLKSLT
     EYRNPTIDLQ NPDQELIKDL LTSLVLRRTG KIEEGCKILD TQVLPQLFTI QNDKVKYIKK
     TEDPWVYPTA FYERALFSWK LKGMNGLHEA HEWLIRAQNY QDDYELSTRI GMKIKAAKDR
     VEESI