ID   IML2_LODEL              Reviewed;         905 AA.
AC   A5E1Y3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; ORFNames=LELG_03620;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CH981527; EDK45441.1; -; Genomic_DNA.
DR   RefSeq; XP_001525692.1; XM_001525642.1.
DR   AlphaFoldDB; A5E1Y3; -.
DR   SMR; A5E1Y3; -.
DR   STRING; 379508.A5E1Y3; -.
DR   EnsemblFungi; EDK45441; EDK45441; LELG_03620.
DR   GeneID; 5232580; -.
DR   KEGG; lel:LELG_03620; -.
DR   VEuPathDB; FungiDB:LELG_03620; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_0_0_1; -.
DR   InParanoid; A5E1Y3; -.
DR   OMA; TYVPGHG; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..905
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333350"
FT   REGION          325..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..356
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  101238 MW;  3C6A177BBFE45547 CRC64;
     MFKGIRKRAS NLSIYAVTSN LSATNAPSDQ QPASNSPSSY ESILSQVHDF EIALKAMDYL
     LDDRTQQGTE LLHEQAQLGS SDGKPHAIFP LALGVMEFIE ATLGFEPEVM ARAHKTLNDA
     ESASTTNAKY NVRHQLATSN IYPPGTEFQV TLAESTLLNA LLMLLTENNG MVESVKALYK
     LRKAYQTLDA VYKKIKELEP VFNRNLAKLR KAANKGLLEV PRLNGLVNGG TRLKHSISTV
     DLPGYESLGS SSSSSSATLP EDLKLMKNLE KIYLMRKARI EGTNLGNNTG VQHQPLNLFS
     DLASSIAMKQ NGNGVETSLP IIPQYGKFNN GNEEQVEEQE EEGEGEEEEE ENSDNEHFVD
     AVEELTIGDI NSSSLADSSA QSILSSVETS PSEVQSTDMH LHVSTTDEFI HSGVQLCFGI
     LQVVLSLIPP AIGKVLSIVG FKGERETGLK LLWKTAITSR NVHGELALLF LLMFYDGPVQ
     FVDTGFRLPS ANKLKNIINL ENKTSVTDDE VELIKDSPES YTSQLLKRAR HHFPHNALWI
     LQEGRMLAAE GRLAQASTLM QNFTDNPNNK IQMQQIEALL IFDRATIYIY MHEYDKAARD
     LIYLIEINSW SKAVYLFMAA ACYLERYRMV RMGLQSPQIN ADTKLSLNGD VELEAKKYSD
     LFTKYLNLSL SYVPGHGANA QKKGGLGGSG KQMPFDKFLL RKWKHIEQRK KRHPELSLAD
     VVGTSLIHEL IYFWNGYNRM SPQDFELALK LLGYSGAPNT ELSANTLHNN YAKIEETEDE
     AMIRYFLQSV ALRQLGKVKQ GLGILDSHVI SKYVISEVPQ FRFHKMTYSP YLYPTAFYEK
     TMFVWLLRTS ESTIKQDVGR AVHECKSYLK KAETVGEGDY ELSNRTSMRI KAAGDRLDQL
     GSLSR