ID   IML2_MAGO7              Reviewed;         804 AA.
AC   A4QTI0; G4N451;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; ORFNames=MGG_05065;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CM001233; EHA52771.1; -; Genomic_DNA.
DR   RefSeq; XP_003712578.1; XM_003712530.1.
DR   AlphaFoldDB; A4QTI0; -.
DR   STRING; 318829.MGG_05065T0; -.
DR   EnsemblFungi; MGG_05065T0; MGG_05065T0; MGG_05065.
DR   GeneID; 2675689; -.
DR   KEGG; mgr:MGG_05065; -.
DR   VEuPathDB; FungiDB:MGG_05065; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   InParanoid; A4QTI0; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; ISS:PAMGO_MGG.
DR   GO; GO:0005634; C:nucleus; ISS:PAMGO_MGG.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..804
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333351"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  88761 MW;  EFB0DFF7EC4BEA44 CRC64;
     MSLRSWFRGS GTTTPKSSAG PSRATTPPSG VQGTVMTAEQ QELADLSDAM QAMAHIMNDD
     PESAEAHLRQ RKDPSSFHLL GLGVSIFMRS ILGFEKDVMA EASKCIADCE TRSWNDKVKG
     ERREPATDGR LFPNGSEFAI VYAQALLMNA VVSVLHESLT DALKAFYKLR KAMAVMSSIS
     AAEEKIMKEQ GASSARGNPF EQASTASGSG NLAAEDEDSD LEFVDADEKV SPEAPIHVTY
     DGHTSTKDST SQPATDAATL EGKLQALEIP DDSDTKSHLS KSAVESQVPS LSASRAPSPG
     PPPQLTDAAS DGSLFTHPID IFIHSAINMC YGSLMLVLSM VPPAFSRLLG IIGFRGDRDK
     GLHMLWQSAA HPNMNGAVAG LLLLGYYHGL LAFADVLPSE RDVAELAEPD EIVGYPRGRC
     IELLRVMRER YPASGLWRME QARVLIGEKK LKEGIEMLEK CGDAKMRQVT ALSTFELAVS
     SICYLDWPRM HSSFVRMVEL NDWSHALYYF IAGCAHLEMY RDAVHELGGL SELSEDGSES
     EKEVKAGDVK VTATKDRLDV EDIRKKELIS NARKYKKSAE TLFRKAPTTA GRKRFMARQM
     PFEVFVMRKV AKWEERATAL KLDLADAIGP SPAAEMIYLW NGGKRMNLEL IEKAMTILEW
     DRCTSSATVA KVKEEHDEVA IHGVGQAALL RHAGRGDEAK GILLDISAYD RATCKGGNKD
     DYILASATYE LAMLAWDDVC RPERWPTDAD EVEEFRRKKT EECYTLLETV AKWETYVLDA
     RFGMRVQTGL DTVRWLSKKK GWTL