ID   IML2_NEOFI              Reviewed;         719 AA.
AC   A1D345;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=NFIA_015310;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; DS027688; EAW22838.1; -; Genomic_DNA.
DR   RefSeq; XP_001264735.1; XM_001264734.1.
DR   AlphaFoldDB; A1D345; -.
DR   STRING; 36630.CADNFIAP00000948; -.
DR   EnsemblFungi; EAW22838; EAW22838; NFIA_015310.
DR   GeneID; 4590991; -.
DR   KEGG; nfi:NFIA_015310; -.
DR   VEuPathDB; FungiDB:NFIA_015310; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..719
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333352"
FT   REGION          177..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  80595 MW;  242061915636FB01 CRC64;
     MFRVGSWLYG KKPAANASTQ SLDSLVELRD PATLILNDDV DGAEAGLAEG TSTFHNLGRG
     VVAFIRATLG FEQDIMRQAS ERLNEAETSA SVDQHRAQHN SHAPNTYHSP MYSPGTEFAL
     CQAIAQLMSA IVGVLNESLT ESIKAFYRLR KAYITLDAIL KMEQKYMEES RSATLVESTT
     SGSVPSSQRH SSSNLQSSSS SISSAKVKEA TADTLAAPSK DTDVNERLAD LSLSGEAPVA
     EDPGQTPTPI NTDILDHDPD SDIFQNQIDV FVHSGSNFCF GVLLLLISMV PPSFSKLLSI
     IGFHGDKERG LKMLWQASKF HNLIGGIAAF AILGYYNGFV RYCDIMPDSI PGKDGDVQGY
     PQKRLELLLA KMRERFPKSQ LWLLEESRMS GANKNLDRAL ELLCGEERSP LKQVEALRVF
     ERSLNAMYLH KYELCADSFL ECVDLNSWSR SLYYYIAGSC HLSLYRDVKE TDSAKAAKHA
     ELAEKYFRMA PTVAGKKRFM ARQLPFDVFV ARKFAKWEAR AKEWKVSLVD AVGIDPIEEM
     IFFWNGHSRM TDEQLQESLQ KLAWSESNAN TTWSREGPEE KAILKLLRAA VHRSLRKHTQ
     AKEMLEDILG QDRTLFKGHL KDDWICPVAH FEMAANLWME RPTYIANHSG AKQDSDKESA
     GPADAKDALQ YERERVRKCK EYLEKAAKWE SYELDARIGL KVTAAMEAVQ KWESTHPTV