ID   IML2_PICGU              Reviewed;         881 AA.
AC   A5DH00;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; ORFNames=PGUG_02551;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CH408157; EDK38453.2; -; Genomic_DNA.
DR   RefSeq; XP_001484822.1; XM_001484772.1.
DR   AlphaFoldDB; A5DH00; -.
DR   STRING; 4929.XP_001484822.1; -.
DR   EnsemblFungi; EDK38453; EDK38453; PGUG_02551.
DR   GeneID; 5127145; -.
DR   KEGG; pgu:PGUG_02551; -.
DR   VEuPathDB; FungiDB:PGUG_02551; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_0_0_1; -.
DR   InParanoid; A5DH00; -.
DR   OMA; TYVPGHG; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..881
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333354"
FT   REGION          206..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   881 AA;  98856 MW;  02E3E356E9450039 CRC64;
     MFKGLRKKAS ALSLTPTSSS ASLGGSNHPQ YSKILKQVRD FEIALRAMDF LLDDRAEEGM
     KLLETESKKH SEMHSDQPAG IFPLAMGVMD FIEATLGFEP EVMARAHETL SNAEAASLTN
     SKYNTKHQLN TSMIYPPGTE FQVTLAESTL LNALVMLLTE NNSFLEAAKA LLKLRKAYQT
     LDSLYKRIKE SEPVFNRNLA KLKRGTSSKN VSTVDLPGFE STDNLGSSNA SSSSLPEDVK
     LMNSLEQIFQ MRKSRVEGTN LGRDVNPDRV NLFKDASSDH IPRMSSLRDL QANPSPRAVS
     PNVALQNSVF SNKPIGTDYD SDEDDDEFTD ALETLQEDIP ISAPMPIYMK SNGGNRIASG
     TESIISFSTD YSASTSSDLN SNHLHVSTID EFIHSGVQLC FGILQVVLSL IPPTIGKVLS
     IVGFKGDFEA GMKMLWRTAI TSRNIHGELA LLCLLVFYDG PIEFIDNGYQ VPNKDSKIAR
     EVFAIDNRST VSDEELKAIT ENPSSYTPQL LERARTHFKH NALWILQQGR MLAAQGQLDE
     AISLMQGFTD DPDNKINMRQ IEGLFLFDRS MLYAFRHSFD ECARDFVKLV DKNSWSQGLY
     LFFAGCSYLE KYRMIKLGLL QVENEQETLK ELAEKAEHFM KLGPTYVPGH GVNAANKKGG
     IGGNKKQLPF DKYLLRKMAH LEEVQKQNPK LAFIDCVGTS PYHEIIYFWN GYNRMPTKDL
     ELSIKLLGYS GAPDSEFSAN TSSNNYSYIK ETMDEAMLRY FFQAMALRSL GRHSEGLALL
     DSHVISKYVT QDSPLANFKF TKMTYSPFLY PTALYEKSRF VWNLRTSAPD FDVRKSITDC
     ETLLKKAEIV SDIGDYEMSS RTSMNIKASL DRVTKLRNQY L