ID   IML2_PICST              Reviewed;         789 AA.
AC   A3GGT0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; ORFNames=PICST_68670;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAVQ01000001; EAZ63587.2; -; Genomic_DNA.
DR   RefSeq; XP_001387610.2; XM_001387573.1.
DR   AlphaFoldDB; A3GGT0; -.
DR   STRING; 4924.XP_001387610.2; -.
DR   EnsemblFungi; EAZ63587; EAZ63587; PICST_68670.
DR   GeneID; 4851479; -.
DR   KEGG; pic:PICST_68670; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_0_0_1; -.
DR   InParanoid; A3GGT0; -.
DR   OMA; FWNGHSR; -.
DR   OrthoDB; 269827at2759; -.
DR   Proteomes; UP000002258; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..789
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333355"
FT   REGION          209..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   789 AA;  88956 MW;  204305D0444F4469 CRC64;
     MLKGLRKKAS ILSISSTQSD TPANNYDKVL KQVRDFEIAL QAMDFLLDDR TDEGTKLLQK
     EAQLHSQSGS DQPAGIFPLA LGVMEFIEAT LGFETEVMER ANRTLSEAET ASLNNSKYNV
     KYSLATSYIY PPGTEFQVTY AESTLLNALV MLLKENNGMV EGAKALFKLR RAYQTLDSVY
     KKIKDSEPIF NKNLSKLKKE SLSNMNNIST SDLPGYKSNS SMSSNGGSSA SLASDVKLMK
     DLEKVYQMRK GRIEGTNLGN NAPEKINFFE GFEDRSSNSS IVSSAATSTS NLSTTESATD
     NQLHVSTVDE FIHSGVQLCF GILQVVLSLI PPAIGKVLSI VGFKGDREIG LKMLWRTAIT
     SRNIHGELAL LCLLVFYDGP VQFVDVGFQL PGHEDSKVKD VLSLDGKTTV SESELKKILQ
     NPALYTPQLL KRARAFFPHN ALWLLQEGRV LAAQGELEKA TQLMQSFTDD KSNKIRMQQV
     EALLVFDRGM FYAFQHDYDN AARDFVKLID INSWSKGVYL FMAASCYLEK YRMIEMGLVD
     VEDKEKELRK YEDLAVKYFE LAPTYVPNHG HNSTSKKQLP FDKFLLRKLR HLEERKRQYP
     KLKFVDLIGT SLIHELVYFW NGYNRMSEKD LQLSLKLLAY SGEVNAELSA NSETASYTKI
     AESEDEAMIR YFLQAIVLRS TGKVSEGLSI LENHVISKYV VADLPQFKFN KMTYSPYLYP
     TALYEKTMFI WILRTTHVEK LDVRKAVQES KNCLKKAEIV GEGDYELSNR TGMRMKAAGD
     RLDQLGHGH