ID   IML2_SCLS1              Reviewed;         645 AA.
AC   A7E727;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Inclusion body clearance protein iml2;
GN   Name=iml2; ORFNames=SS1G_01103;
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CH476622; EDN96179.1; -; Genomic_DNA.
DR   RefSeq; XP_001596911.1; XM_001596861.1.
DR   AlphaFoldDB; A7E727; -.
DR   STRING; 665079.A7E727; -.
DR   PRIDE; A7E727; -.
DR   EnsemblFungi; EDN96179; EDN96179; SS1G_01103.
DR   GeneID; 5493696; -.
DR   KEGG; ssl:SS1G_01103; -.
DR   eggNOG; KOG3783; Eukaryota.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   InParanoid; A7E727; -.
DR   OMA; IATQEEW; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..645
FT                   /note="Inclusion body clearance protein iml2"
FT                   /id="PRO_0000333357"
SQ   SEQUENCE   645 AA;  72846 MW;  9D788AD86A96AF69 CRC64;
     MSRWFKSAVK ATPAMVAESE EQHLRDVEAA MLKLLNDDIE EADKLLKKHD SSYHHLGRGI
     SGFLSAMMGV EKDLLKEAAV ILQDAENKSW DDMKKAQKDS TAFQSNIYPQ GTEYLLCYSV
     AQLTSAITAV LSGSITEAVK GFYKLRKAYL TLDGILEVEN KYLEKIAHSS TTSLSSRTPS
     HKSSMAALTV DEIAHRTADL SVGDLDEKML DPNNPYPNIS RPPSPPSVTN PYDIDPELAA
     RVFTNRTDIF IHSGVRLCCG LLLLVFSMIE NPIFNKILYI VGFKGDRERG TRLLWQATRY
     QNFNSAIAAL ALLGYYNGLV GFCDILPTDD AADDNPTGYP KNKCQALLVD MQSRYPHSKL
     WKLEEARMLS YKQDLKGALV ILEENSKSKM KQITMINTFE MALTTLFIHE YEKSATAWIN
     CSEQSAWSPT LYFYIAGISY VELYRNTRLS DPAAAEVHKK KAIEFILKAP PLAGKQKVMA
     KQLPFDIYIV SKVGKWEQRA KAWGVDLVDA IGPSPFVEMI YFWNGVKKSG TVELEKCLDL
     LKKERMTCPE KCNEDEEDVA IHLLLRGSCC SWREKDLPPG GDSTSGEKMS EKKLLEYRRE
     KLMDCEEKLL KLHSWPQTYV FETRMSFKIS TSLLTVKRHK GLMGF