ID   IML2_YARLI              Reviewed;         721 AA.
AC   Q6BZZ6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Inclusion body clearance protein IML2;
GN   Name=IML2; OrderedLocusNames=YALI0F29491g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Inclusion body (IB) resident protein that interacts strongly
CC       with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing
CC       after protein folding stress, probably by enabling access to the IBs of
CC       an LD-stored soluble sterol derivative that acts as chaperone in
CC       inclusion clearing. {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBUNIT: Interacts with lipid droplet proteins.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47031}. Nucleus
CC       {ECO:0000250|UniProtKB:P47031}. Note=Localized exclusively in
CC       cytoplasmic inclusion bodies under protein folding stress conditions.
CC       {ECO:0000250|UniProtKB:P47031}.
CC   -!- SIMILARITY: Belongs to the IML2 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78829.1; -; Genomic_DNA.
DR   RefSeq; XP_506016.1; XM_506016.1.
DR   AlphaFoldDB; Q6BZZ6; -.
DR   STRING; 4952.CAG78829; -.
DR   EnsemblFungi; CAG78829; CAG78829; YALI0_F29491g.
DR   GeneID; 2908731; -.
DR   KEGG; yli:YALI0F29491g; -.
DR   VEuPathDB; FungiDB:YALI0_F29491g; -.
DR   HOGENOM; CLU_014926_1_0_1; -.
DR   InParanoid; Q6BZZ6; -.
DR   OMA; FWNGHSR; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019412; Iml2/TPR_39.
DR   PANTHER; PTHR31859; PTHR31859; 1.
DR   Pfam; PF10300; DUF3808; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..721
FT                   /note="Inclusion body clearance protein IML2"
FT                   /id="PRO_0000333359"
SQ   SEQUENCE   721 AA;  80282 MW;  8F05435492DA7283 CRC64;
     MLKALGLGKR GGDMPTKPLN NSTVSLAIMD DALRVEEAFI AMDMVMDDRS KEALKLIQKD
     EPGSSGKSVA REQSAFYKLV IGVIYFIEAT LGFEPESIRR ASEALAEAEA AAVRQKRNVS
     NNGAHVSYSK YPPGTEYRVA FAEAELMGAI TLFLSESYLE SVKALYKLRK AYQTLDEISK
     SIRESKKPAK SSDHKSTLDS LSLAVSDDQE MASLVEKFQK TRLNRLNESN NATPVASSAA
     SMNTTTSSAT ALHQGSETIE EFIESGVDLC FGILQLVISI IPPTLGKILS VVGFRGSRDG
     GLSLLWEATN YRNIHGALAL LVLLQFYDGP TQFSDLILPG TEEDLIQQGK YDINTADDTE
     ITLTATITGG SGHSKKVHTL PKNPRRRMHK LLLAARGYYP HSALWMLQQG RMEASQCHLE
     KAVDIMDADI GPIEMKQVEA LMLFDKTMFM LFLNRYEQSA TNFIRLIDIN AWSHAWYTYV
     AATCSIEIYR ENLRAGNAEA AKKAKDTATR LLTEAPGLIG KKKLMAKTMP MDVFLSRKIS
     QMQQLSKQHN IDLVDAAGVS PVQEVVYFWN GYGKMPEYAL EKVFSEVLAY SAAPLAPSHI
     PEQDNEKTVR HLLQAVALRN MGKVEEGYKI LNDNVISQII TESNNKYHYN KTVTHKDPWM
     PPSALYERAM FEWVMHGPKG TETVREWLHL AEKWSDDYEL STRVGMKIKS AFERLDGGAL
     A