ID   IMMC_TABYA              Reviewed;          68 AA.
AC   C1IC04;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 11.
DE   RecName: Full=Tabimmunregulin 12 {ECO:0000303|PubMed:18087067};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ABX80092.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 39-68, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Salivary gland;
RX   PubMed=18087067; DOI=10.1074/mcp.m700497-mcp200;
RA   Xu X., Yang H., Ma D., Wu J., Wang Y., Song Y., Wang X., Lu Y., Yang J.,
RA   Lai R.;
RT   "Toward an understanding of the molecular mechanism for successful blood
RT   feeding by coupling proteomics analysis with pharmacological testing of
RT   horsefly salivary glands.";
RL   Mol. Cell. Proteomics 7:582-590(2008).
CC   -!- FUNCTION: Horsefly salivary gland immunosuppressant protein that likely
CC       inhibits the host inflammatory response by regulation of anti- and pro-
CC       inflammatory cytokines (PubMed:18087067). When tested on mouse
CC       splenocytes in the presence of LPS, it increases the secretion of the
CC       proinflammatory cytokine interleukin-10 (IL10) and decreases the
CC       secretion of the proinflammatory cytokine interferon-gamma (IFNG) in a
CC       dose-dependent manner (PubMed:18087067). {ECO:0000269|PubMed:18087067}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18087067}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:18087067}.
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DR   EMBL; EU147275; ABX80092.1; -; mRNA.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..38
FT                   /evidence="ECO:0000305|PubMed:18087067"
FT                   /id="PRO_0000456098"
FT   PEPTIDE         39..68
FT                   /note="Tabimmunregulin 12"
FT                   /evidence="ECO:0000269|PubMed:18087067"
FT                   /id="PRO_5002908927"
SQ   SEQUENCE   68 AA;  7351 MW;  8D35FBA45A3793A4 CRC64;
     MLFKSYVYFL AGLLLVGLFT SCDADAQYEE LVPGFFRKGG VSGVGDYKPI VVFGKSFNQF
     EAAEGAKG