IMP3_HUMAN
ID IMP3_HUMAN Reviewed; 184 AA.
AC Q9NV31; B3KQ67; Q53G10;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP3;
DE Short=U3 snoRNP protein IMP3;
DE AltName: Full=BRMS2;
GN Name=IMP3; Synonyms=C15orf12, MRPS4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Samant R.S., Seraj J., Sakamaki T., Verderame M.F., Welch D.R.;
RT "Potential metastasis suppressor gene(s) in chromosome 11 hybrid of MDA MB
RT 435 breast carcinoma cell line.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MPHOSPH10.
RX PubMed=12655004; DOI=10.1093/nar/gkg300;
RA Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W.,
RA van Venrooij W.J., Baserga S.J., Pruijn G.J.M.;
RT "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which
RT only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.";
RL Nucleic Acids Res. 31:1877-1887(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP STRUCTURE BY NMR OF 109-166.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the S4 domain of U3 small nucleolar
RT ribonucleoprotein protein IMP3 homolog.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC RNA processing. {ECO:0000269|PubMed:12655004}.
CC -!- SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4
CC and MPHOSPH10. Interacts with MPHOSPH10. {ECO:0000269|PubMed:12655004}.
CC -!- INTERACTION:
CC Q9NV31; O95273: CCNDBP1; NbExp=6; IntAct=EBI-747481, EBI-748961;
CC Q9NV31; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-747481, EBI-743105;
CC Q9NV31; O60447: EVI5; NbExp=3; IntAct=EBI-747481, EBI-852291;
CC Q9NV31; Q6P597: KLC3; NbExp=3; IntAct=EBI-747481, EBI-1643885;
CC Q9NV31; P23508: MCC; NbExp=3; IntAct=EBI-747481, EBI-307531;
CC Q9NV31; O00566: MPHOSPH10; NbExp=2; IntAct=EBI-747481, EBI-5235884;
CC Q9NV31; P60323-2: NANOS3; NbExp=3; IntAct=EBI-747481, EBI-18012223;
CC Q9NV31; Q9BZL4: PPP1R12C; NbExp=3; IntAct=EBI-747481, EBI-721802;
CC Q9NV31; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-747481, EBI-748621;
CC Q9NV31; O60504: SORBS3; NbExp=3; IntAct=EBI-747481, EBI-741237;
CC Q9NV31; Q9UBB9: TFIP11; NbExp=4; IntAct=EBI-747481, EBI-1105213;
CC Q9NV31; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-747481, EBI-739895;
CC Q9NV31; Q8N720: ZNF655; NbExp=3; IntAct=EBI-747481, EBI-625509;
CC Q9NV31; Q15942: ZYX; NbExp=8; IntAct=EBI-747481, EBI-444225;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12655004}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000305}.
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DR EMBL; AY050497; AAL06639.1; -; mRNA.
DR EMBL; AL136913; CAB66847.1; -; mRNA.
DR EMBL; AK001830; BAA91929.1; -; mRNA.
DR EMBL; AK057531; BAG51929.1; -; mRNA.
DR EMBL; AK223121; BAD96841.1; -; mRNA.
DR EMBL; CH471136; EAW99244.1; -; Genomic_DNA.
DR EMBL; BC006487; AAH06487.1; -; mRNA.
DR EMBL; BC011745; AAH11745.1; -; mRNA.
DR CCDS; CCDS10282.1; -.
DR RefSeq; NP_060755.1; NM_018285.3.
DR PDB; 2CQJ; NMR; -; A=109-166.
DR PDB; 7MQ8; EM; 3.60 A; LZ=1-184.
DR PDB; 7MQ9; EM; 3.87 A; LZ=1-184.
DR PDB; 7MQA; EM; 2.70 A; LZ=1-184.
DR PDBsum; 2CQJ; -.
DR PDBsum; 7MQ8; -.
DR PDBsum; 7MQ9; -.
DR PDBsum; 7MQA; -.
DR AlphaFoldDB; Q9NV31; -.
DR SMR; Q9NV31; -.
DR BioGRID; 120560; 128.
DR ComplexPortal; CPX-2478; MPP10 complex.
DR CORUM; Q9NV31; -.
DR IntAct; Q9NV31; 38.
DR MINT; Q9NV31; -.
DR STRING; 9606.ENSP00000326981; -.
DR iPTMnet; Q9NV31; -.
DR PhosphoSitePlus; Q9NV31; -.
DR SwissPalm; Q9NV31; -.
DR BioMuta; IMP3; -.
DR DMDM; 52783099; -.
DR EPD; Q9NV31; -.
DR jPOST; Q9NV31; -.
DR MassIVE; Q9NV31; -.
DR MaxQB; Q9NV31; -.
DR PaxDb; Q9NV31; -.
DR PeptideAtlas; Q9NV31; -.
DR PRIDE; Q9NV31; -.
DR ProteomicsDB; 82742; -.
DR Antibodypedia; 43256; 238 antibodies from 30 providers.
DR DNASU; 55272; -.
DR Ensembl; ENST00000314852.2; ENSP00000326981.2; ENSG00000177971.9.
DR Ensembl; ENST00000403490.3; ENSP00000385217.1; ENSG00000177971.9.
DR GeneID; 55272; -.
DR KEGG; hsa:55272; -.
DR MANE-Select; ENST00000403490.3; ENSP00000385217.1; NM_018285.4; NP_060755.1.
DR UCSC; uc002bat.3; human.
DR CTD; 55272; -.
DR DisGeNET; 55272; -.
DR GeneCards; IMP3; -.
DR HGNC; HGNC:14497; IMP3.
DR HPA; ENSG00000177971; Low tissue specificity.
DR MIM; 612980; gene.
DR neXtProt; NX_Q9NV31; -.
DR OpenTargets; ENSG00000177971; -.
DR PharmGKB; PA25517; -.
DR VEuPathDB; HostDB:ENSG00000177971; -.
DR eggNOG; KOG4655; Eukaryota.
DR GeneTree; ENSGT00550000075090; -.
DR HOGENOM; CLU_097281_0_0_1; -.
DR InParanoid; Q9NV31; -.
DR OMA; KVDFLDW; -.
DR OrthoDB; 1336285at2759; -.
DR PhylomeDB; Q9NV31; -.
DR TreeFam; TF300149; -.
DR PathwayCommons; Q9NV31; -.
DR Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9NV31; -.
DR SIGNOR; Q9NV31; -.
DR BioGRID-ORCS; 55272; 787 hits in 1059 CRISPR screens.
DR ChiTaRS; IMP3; human.
DR EvolutionaryTrace; Q9NV31; -.
DR GeneWiki; IMP3; -.
DR GenomeRNAi; 55272; -.
DR Pharos; Q9NV31; Tbio.
DR PRO; PR:Q9NV31; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9NV31; protein.
DR Bgee; ENSG00000177971; Expressed in mucosa of transverse colon and 199 other tissues.
DR Genevisible; Q9NV31; HS.
DR GO; GO:0034457; C:Mpp10 complex; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; IDA:HGNC-UCL.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0030684; C:preribosome; IDA:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IC:ComplexPortal.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing; rRNA-binding.
FT CHAIN 1..184
FT /note="U3 small nucleolar ribonucleoprotein protein IMP3"
FT /id="PRO_0000132709"
FT DOMAIN 109..175
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT CONFLICT 15
FT /note="Q -> R (in Ref. 4; BAD96841)"
FT /evidence="ECO:0000305"
FT HELIX 111..117
FT /evidence="ECO:0007829|PDB:2CQJ"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:2CQJ"
FT HELIX 124..132
FT /evidence="ECO:0007829|PDB:2CQJ"
FT STRAND 136..138
FT /evidence="ECO:0007829|PDB:2CQJ"
FT STRAND 149..151
FT /evidence="ECO:0007829|PDB:2CQJ"
FT HELIX 152..155
FT /evidence="ECO:0007829|PDB:2CQJ"
FT STRAND 158..161
FT /evidence="ECO:0007829|PDB:2CQJ"
FT STRAND 164..166
FT /evidence="ECO:0007829|PDB:2CQJ"
SQ SEQUENCE 184 AA; 21850 MW; AAE0352DF7C790F1 CRC64;
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR
RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF VTASSFCRRR LPTVLLKLRM
AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF
DLEA
