IMP3_MOUSE
ID IMP3_MOUSE Reviewed; 184 AA.
AC Q921Y2;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP3;
DE Short=U3 snoRNP protein IMP3;
GN Name=Imp3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC RNA processing (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4
CC and MPHOSPH10. Interacts with MPHOSPH10 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000305}.
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DR EMBL; BC009145; AAH09145.1; -; mRNA.
DR CCDS; CCDS23213.1; -.
DR RefSeq; NP_598737.1; NM_133976.2.
DR AlphaFoldDB; Q921Y2; -.
DR SMR; Q921Y2; -.
DR BioGRID; 221882; 26.
DR STRING; 10090.ENSMUSP00000034827; -.
DR PhosphoSitePlus; Q921Y2; -.
DR SwissPalm; Q921Y2; -.
DR EPD; Q921Y2; -.
DR MaxQB; Q921Y2; -.
DR PaxDb; Q921Y2; -.
DR PeptideAtlas; Q921Y2; -.
DR PRIDE; Q921Y2; -.
DR ProteomicsDB; 269311; -.
DR Antibodypedia; 43256; 238 antibodies from 30 providers.
DR DNASU; 102462; -.
DR Ensembl; ENSMUST00000034827; ENSMUSP00000034827; ENSMUSG00000032288.
DR GeneID; 102462; -.
DR KEGG; mmu:102462; -.
DR UCSC; uc009ptq.1; mouse.
DR CTD; 55272; -.
DR MGI; MGI:1916119; Imp3.
DR VEuPathDB; HostDB:ENSMUSG00000032288; -.
DR eggNOG; KOG4655; Eukaryota.
DR GeneTree; ENSGT00550000075090; -.
DR HOGENOM; CLU_097281_0_0_1; -.
DR InParanoid; Q921Y2; -.
DR OMA; KVDFLDW; -.
DR OrthoDB; 1336285at2759; -.
DR PhylomeDB; Q921Y2; -.
DR TreeFam; TF300149; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 102462; 25 hits in 68 CRISPR screens.
DR PRO; PR:Q921Y2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q921Y2; protein.
DR Bgee; ENSMUSG00000032288; Expressed in medial ganglionic eminence and 257 other tissues.
DR Genevisible; Q921Y2; MM.
DR GO; GO:0034457; C:Mpp10 complex; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0030684; C:preribosome; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IGI:MGI.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW RNA-binding; rRNA processing; rRNA-binding.
FT CHAIN 1..184
FT /note="U3 small nucleolar ribonucleoprotein protein IMP3"
FT /id="PRO_0000132710"
FT DOMAIN 109..175
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
SQ SEQUENCE 184 AA; 21777 MW; 5BFC2B6C600B8166 CRC64;
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREEYTRYNQ LSRAVRELAR
RLRDLPERDP FRVRASAALL DKLYAMGLVP TRGSLELCDS VSASSFCRRR LPTLLLKLRM
AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF
DLDA