ID   IMP3_MOUSE              Reviewed;         184 AA.
AC   Q921Y2;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP3;
DE            Short=U3 snoRNP protein IMP3;
GN   Name=Imp3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC       (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC       RNA processing (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4
CC       and MPHOSPH10. Interacts with MPHOSPH10 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC       {ECO:0000305}.
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DR   EMBL; BC009145; AAH09145.1; -; mRNA.
DR   CCDS; CCDS23213.1; -.
DR   RefSeq; NP_598737.1; NM_133976.2.
DR   AlphaFoldDB; Q921Y2; -.
DR   SMR; Q921Y2; -.
DR   BioGRID; 221882; 26.
DR   STRING; 10090.ENSMUSP00000034827; -.
DR   PhosphoSitePlus; Q921Y2; -.
DR   SwissPalm; Q921Y2; -.
DR   EPD; Q921Y2; -.
DR   MaxQB; Q921Y2; -.
DR   PaxDb; Q921Y2; -.
DR   PeptideAtlas; Q921Y2; -.
DR   PRIDE; Q921Y2; -.
DR   ProteomicsDB; 269311; -.
DR   Antibodypedia; 43256; 238 antibodies from 30 providers.
DR   DNASU; 102462; -.
DR   Ensembl; ENSMUST00000034827; ENSMUSP00000034827; ENSMUSG00000032288.
DR   GeneID; 102462; -.
DR   KEGG; mmu:102462; -.
DR   UCSC; uc009ptq.1; mouse.
DR   CTD; 55272; -.
DR   MGI; MGI:1916119; Imp3.
DR   VEuPathDB; HostDB:ENSMUSG00000032288; -.
DR   eggNOG; KOG4655; Eukaryota.
DR   GeneTree; ENSGT00550000075090; -.
DR   HOGENOM; CLU_097281_0_0_1; -.
DR   InParanoid; Q921Y2; -.
DR   OMA; KVDFLDW; -.
DR   OrthoDB; 1336285at2759; -.
DR   PhylomeDB; Q921Y2; -.
DR   TreeFam; TF300149; -.
DR   Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   BioGRID-ORCS; 102462; 25 hits in 68 CRISPR screens.
DR   PRO; PR:Q921Y2; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q921Y2; protein.
DR   Bgee; ENSMUSG00000032288; Expressed in medial ganglionic eminence and 257 other tissues.
DR   Genevisible; Q921Y2; MM.
DR   GO; GO:0034457; C:Mpp10 complex; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0030684; C:preribosome; ISO:MGI.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IGI:MGI.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR022801; Ribosomal_S4/S9.
DR   InterPro; IPR001912; Ribosomal_S4/S9_N.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11831; PTHR11831; 1.
DR   Pfam; PF00163; Ribosomal_S4; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM01390; Ribosomal_S4; 1.
DR   SMART; SM00363; S4; 1.
DR   PROSITE; PS50889; S4; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   RNA-binding; rRNA processing; rRNA-binding.
FT   CHAIN           1..184
FT                   /note="U3 small nucleolar ribonucleoprotein protein IMP3"
FT                   /id="PRO_0000132710"
FT   DOMAIN          109..175
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
SQ   SEQUENCE   184 AA;  21777 MW;  5BFC2B6C600B8166 CRC64;
     MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREEYTRYNQ LSRAVRELAR
     RLRDLPERDP FRVRASAALL DKLYAMGLVP TRGSLELCDS VSASSFCRRR LPTLLLKLRM
     AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF
     DLDA