ID   IMP4_HUMAN              Reviewed;         291 AA.
AC   Q96G21; Q3ZTT3;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP4;
DE            Short=U3 snoRNP protein IMP4;
DE   AltName: Full=Brix domain-containing protein 4;
GN   Name=IMP4; Synonyms=BXDC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=16533400; DOI=10.1186/1471-2164-7-48;
RA   Kemmer D., Podowski R.M., Arenillas D., Lim J., Hodges E., Roth P.,
RA   Sonnhammer E.L.L., Hoeoeg C., Wasserman W.W.;
RT   "NovelFam3000 -- uncharacterized human protein domains conserved across
RT   model organisms.";
RL   BMC Genomics 7:48-48(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Caudate nucleus, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MPHOSPH10.
RX   PubMed=12655004; DOI=10.1093/nar/gkg300;
RA   Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W.,
RA   van Venrooij W.J., Baserga S.J., Pruijn G.J.M.;
RT   "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which
RT   only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.";
RL   Nucleic Acids Res. 31:1877-1887(2003).
CC   -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC       (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC       RNA processing. {ECO:0000269|PubMed:12655004}.
CC   -!- SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4
CC       and MPHOSPH10. Interacts with MPHOSPH10. {ECO:0000269|PubMed:12655004}.
CC   -!- INTERACTION:
CC       Q96G21; O00566: MPHOSPH10; NbExp=2; IntAct=EBI-8641721, EBI-5235884;
CC       Q96G21; O15156: ZBTB7B; NbExp=4; IntAct=EBI-8641721, EBI-740434;
CC       Q96G21; O15156-2: ZBTB7B; NbExp=3; IntAct=EBI-8641721, EBI-11522250;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12655004,
CC       ECO:0000269|PubMed:16533400}.
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DR   EMBL; AY364245; AAQ76804.1; -; mRNA.
DR   EMBL; AK289878; BAF82567.1; -; mRNA.
DR   EMBL; AK292345; BAF85034.1; -; mRNA.
DR   EMBL; AK312808; BAG35666.1; -; mRNA.
DR   EMBL; AC132479; AAY24076.1; -; Genomic_DNA.
DR   EMBL; BC010042; AAH10042.1; -; mRNA.
DR   CCDS; CCDS2160.1; -.
DR   RefSeq; NP_001307233.1; NM_001320304.1.
DR   RefSeq; NP_001307234.1; NM_001320305.1.
DR   RefSeq; NP_001307235.1; NM_001320306.1.
DR   RefSeq; NP_001307236.1; NM_001320307.1.
DR   RefSeq; NP_001307238.1; NM_001320309.1.
DR   RefSeq; NP_001307239.1; NM_001320310.1.
DR   RefSeq; NP_001307240.1; NM_001320311.1.
DR   RefSeq; NP_219484.1; NM_033416.2.
DR   PDB; 7MQ8; EM; 3.60 A; SM=1-291.
DR   PDB; 7MQ9; EM; 3.87 A; SM=1-291.
DR   PDB; 7MQA; EM; 2.70 A; SM=1-291.
DR   PDBsum; 7MQ8; -.
DR   PDBsum; 7MQ9; -.
DR   PDBsum; 7MQA; -.
DR   AlphaFoldDB; Q96G21; -.
DR   SMR; Q96G21; -.
DR   BioGRID; 124984; 114.
DR   ComplexPortal; CPX-2478; MPP10 complex.
DR   CORUM; Q96G21; -.
DR   IntAct; Q96G21; 26.
DR   MINT; Q96G21; -.
DR   STRING; 9606.ENSP00000259239; -.
DR   iPTMnet; Q96G21; -.
DR   PhosphoSitePlus; Q96G21; -.
DR   SwissPalm; Q96G21; -.
DR   BioMuta; IMP4; -.
DR   DMDM; 73621060; -.
DR   EPD; Q96G21; -.
DR   jPOST; Q96G21; -.
DR   MassIVE; Q96G21; -.
DR   MaxQB; Q96G21; -.
DR   PaxDb; Q96G21; -.
DR   PeptideAtlas; Q96G21; -.
DR   PRIDE; Q96G21; -.
DR   ProteomicsDB; 76583; -.
DR   Antibodypedia; 47574; 122 antibodies from 22 providers.
DR   DNASU; 92856; -.
DR   Ensembl; ENST00000259239.8; ENSP00000259239.3; ENSG00000136718.10.
DR   GeneID; 92856; -.
DR   KEGG; hsa:92856; -.
DR   MANE-Select; ENST00000259239.8; ENSP00000259239.3; NM_033416.3; NP_219484.1.
DR   UCSC; uc002tra.2; human.
DR   CTD; 92856; -.
DR   DisGeNET; 92856; -.
DR   GeneCards; IMP4; -.
DR   HGNC; HGNC:30856; IMP4.
DR   HPA; ENSG00000136718; Low tissue specificity.
DR   MIM; 612981; gene.
DR   neXtProt; NX_Q96G21; -.
DR   OpenTargets; ENSG00000136718; -.
DR   PharmGKB; PA142671656; -.
DR   VEuPathDB; HostDB:ENSG00000136718; -.
DR   eggNOG; KOG2781; Eukaryota.
DR   GeneTree; ENSGT00940000153231; -.
DR   InParanoid; Q96G21; -.
DR   OMA; IGTMSEQ; -.
DR   OrthoDB; 768872at2759; -.
DR   PhylomeDB; Q96G21; -.
DR   TreeFam; TF300016; -.
DR   PathwayCommons; Q96G21; -.
DR   Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol.
DR   Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   SignaLink; Q96G21; -.
DR   SIGNOR; Q96G21; -.
DR   BioGRID-ORCS; 92856; 734 hits in 1076 CRISPR screens.
DR   ChiTaRS; IMP4; human.
DR   GeneWiki; IMP4; -.
DR   GenomeRNAi; 92856; -.
DR   Pharos; Q96G21; Tdark.
DR   PRO; PR:Q96G21; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q96G21; protein.
DR   Bgee; ENSG00000136718; Expressed in body of pancreas and 198 other tissues.
DR   ExpressionAtlas; Q96G21; baseline and differential.
DR   Genevisible; Q96G21; HS.
DR   GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR   GO; GO:0034457; C:Mpp10 complex; IDA:MGI.
DR   GO; GO:0005730; C:nucleolus; IDA:HGNC-UCL.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0030684; C:preribosome; IDA:MGI.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IC:ComplexPortal.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR044281; IMP4/RPF1.
DR   PANTHER; PTHR22734; PTHR22734; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Nucleus; Reference proteome; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..291
FT                   /note="U3 small nucleolar ribonucleoprotein protein IMP4"
FT                   /id="PRO_0000120236"
FT   DOMAIN          83..264
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
SQ   SEQUENCE   291 AA;  33757 MW;  460A05DFFE70C580 CRC64;
     MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA LALQGSLEFD
     DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF AKELKLVFPG AQRMNRGRHE
     VGALVRACKA NGVTDLLVVH EHRGTPVGLI VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS
     EAKPHLITHG FSSRLGKRVS DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR
     NVELTEVGPR FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLST E