IMP4_MOUSE
ID IMP4_MOUSE Reviewed; 291 AA.
AC Q8VHZ7; Q3U8H6; Q8CI42; Q9CWN6; Q9CYT5;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP4;
DE Short=U3 snoRNP protein IMP4;
GN Name=Imp4; Synonyms=D1Wsu40e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12655004; DOI=10.1093/nar/gkg300;
RA Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W.,
RA van Venrooij W.J., Baserga S.J., Pruijn G.J.M.;
RT "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which
RT only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.";
RL Nucleic Acids Res. 31:1877-1887(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC RNA processing (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4
CC and MPHOSPH10. Interacts with MPHOSPH10 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26989.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF334609; AAL73190.1; -; mRNA.
DR EMBL; AK010504; BAB26989.1; ALT_FRAME; mRNA.
DR EMBL; AK013334; BAB28797.1; -; mRNA.
DR EMBL; AK084933; BAC39313.1; -; mRNA.
DR EMBL; AK151176; BAE30178.1; -; mRNA.
DR EMBL; AK152214; BAE31042.1; -; mRNA.
DR EMBL; AK166903; BAE39105.1; -; mRNA.
DR EMBL; BC037602; AAH37602.1; -; mRNA.
DR EMBL; BC069930; AAH69930.1; -; mRNA.
DR CCDS; CCDS35536.1; -.
DR RefSeq; NP_848716.2; NM_178601.3.
DR AlphaFoldDB; Q8VHZ7; -.
DR SMR; Q8VHZ7; -.
DR BioGRID; 205703; 2.
DR IntAct; Q8VHZ7; 1.
DR STRING; 10090.ENSMUSP00000027303; -.
DR PhosphoSitePlus; Q8VHZ7; -.
DR EPD; Q8VHZ7; -.
DR MaxQB; Q8VHZ7; -.
DR PaxDb; Q8VHZ7; -.
DR PeptideAtlas; Q8VHZ7; -.
DR PRIDE; Q8VHZ7; -.
DR ProteomicsDB; 267332; -.
DR Antibodypedia; 47574; 122 antibodies from 22 providers.
DR Ensembl; ENSMUST00000027303; ENSMUSP00000027303; ENSMUSG00000026127.
DR GeneID; 27993; -.
DR KEGG; mmu:27993; -.
DR UCSC; uc007aor.2; mouse.
DR CTD; 92856; -.
DR MGI; MGI:106572; Imp4.
DR VEuPathDB; HostDB:ENSMUSG00000026127; -.
DR eggNOG; KOG2781; Eukaryota.
DR GeneTree; ENSGT00940000153231; -.
DR HOGENOM; CLU_040063_2_0_1; -.
DR InParanoid; Q8VHZ7; -.
DR OMA; IGTMSEQ; -.
DR OrthoDB; 768872at2759; -.
DR PhylomeDB; Q8VHZ7; -.
DR TreeFam; TF300016; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 27993; 24 hits in 74 CRISPR screens.
DR ChiTaRS; Imp4; mouse.
DR PRO; PR:Q8VHZ7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8VHZ7; protein.
DR Bgee; ENSMUSG00000026127; Expressed in animal zygote and 270 other tissues.
DR ExpressionAtlas; Q8VHZ7; baseline and differential.
DR Genevisible; Q8VHZ7; MM.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0034457; C:Mpp10 complex; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISS:HGNC-UCL.
DR GO; GO:0030684; C:preribosome; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR044281; IMP4/RPF1.
DR PANTHER; PTHR22734; PTHR22734; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..291
FT /note="U3 small nucleolar ribonucleoprotein protein IMP4"
FT /id="PRO_0000120237"
FT DOMAIN 83..264
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT CONFLICT 22..23
FT /note="QR -> HG (in Ref. 2; BAB28797)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 33656 MW; 5AFF74AA16E0C7BC CRC64;
MLRREARLRR EYLYRKAREE AQRSVQEKKE RVKRALEENQ LIPTELRREA LALQGSLEFD
DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF AKELKLVFPG AQRMNRGRHE
VGALVRACKA NGVTDLLVVH EHRGTPVGLI VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS
EAKPHLITHG FSSRLGKRVS DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR
NVELTEVGPR FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLSA E
